Volume 63, Issue 4, Pages (April 2003)

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Volume 63, Issue 4, Pages 1540-1547 (April 2003) Studies on dialysate mixing in the Genius® single-pass batch system for hemodialysis therapy Annemieke W. Dhondt, Raymond C. Vanholder, Rita V. De Smet, Stefaan A. Claus, Marie-Anne Waterloos, Griet L. Glorieux, Joris R. Delanghe, Norbert H. Lameire Kidney International Volume 63, Issue 4, Pages 1540-1547 (April 2003) DOI: 10.1046/j.1523-1755.2003.00862.x Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 1 Flow chart of the Genius® dialysis system. The circulator (1), closed container with 75 L dialysate (2), spent dialysate (3), unused dialysate (4), dialyzer (5), ultrafiltrate recipient (6), arterial bloodline (7), venous bloodline (8), sampling port at the inlet dialysate line (9), and sampling port at the outlet dialysate line (10). Kidney International 2003 63, 1540-1547DOI: (10.1046/j.1523-1755.2003.00862.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 2 Dialysate concentrations. Inlet dialysate concentration (lower lines) and outlet dialysate concentration (upper lines) in mg/dL of urea (A), creatinine (B), p-cresol (C), hippuric acid (D), indoxyl sulfate (E), and osmolality in mosm/kg (F). Full line, dialysate temperature at 37°C; and dotted line, temperature at 38.5°C. Kidney International 2003 63, 1540-1547DOI: (10.1046/j.1523-1755.2003.00862.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 3 Measured dialysate concentration of urea at inlet dialysate line (▪) and outlet line (▴). Kidney International 2003 63, 1540-1547DOI: (10.1046/j.1523-1755.2003.00862.x) Copyright © 2003 International Society of Nephrology Terms and Conditions

Figure 4 Measured dialysate concentration of urea at inlet dialysate line (full line) (▪) and theoretically expected dialysate concentration at inlet line in the assumed absence of mixing (dotted line) (▴). Kidney International 2003 63, 1540-1547DOI: (10.1046/j.1523-1755.2003.00862.x) Copyright © 2003 International Society of Nephrology Terms and Conditions