Guideline 1: Detection and evaluation of HCV in CKD

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Guideline 1: Detection and evaluation of HCV in CKD Kidney International Volume 73, Pages S10-S19 (April 2008) DOI: 10.1038/ki.2008.84 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Summary receiver operating characteristic curve: EIA vs NAT.*For Khan (at Sn 72%, Sp 97%), the oval size is for the actual numbers analyzed. For each study, the prevalence of HCV per NAT/EIA testing, the location, and the quality are noted. Black ovals indicate 3rd generation EIA, grey ovals indicate 2nd generation EIA. Kidney International 2008 73, S10-S19DOI: (10.1038/ki.2008.84) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Probability of HCV infection based on population prevalence and EIA test accuracy. (a) Low sensitivity, high specificity; (b) approximated from pooled estimates of sensitivity and specificity; (c) high sensitivity, low specificity. Abbreviations: EIA: enzyme immunoassay; NAT: nucleic acid test. Kidney International 2008 73, S10-S19DOI: (10.1038/ki.2008.84) Copyright © 2008 International Society of Nephrology Terms and Conditions

Algorithm 1 CKD Stage 5 hemodialysis diagnostic algorithm. Please refer to the rationale text for a detailed explanation of the impact of pretest probability of HCV+ on the choice of HCV test. In particular, note that after a negative primary NAT, a patient can be considered to be at low probability of HCV infection (unless other factors change) so that subsequent testing by EIA is appropriate. ALT, alanine aminotransferase; AST, aspartate aminotransferase; CKD: chronic kidney disease; EIA: enzyme immunoassay; HCV: hepatitis C virus; NAT: nucleic acid test. Kidney International 2008 73, S10-S19DOI: (10.1038/ki.2008.84) Copyright © 2008 International Society of Nephrology Terms and Conditions

Kidney International 2008 73, S10-S19DOI: (10.1038/ki.2008.84) Copyright © 2008 International Society of Nephrology Terms and Conditions

Kidney International 2008 73, S10-S19DOI: (10.1038/ki.2008.84) Copyright © 2008 International Society of Nephrology Terms and Conditions

Kidney International 2008 73, S10-S19DOI: (10.1038/ki.2008.84) Copyright © 2008 International Society of Nephrology Terms and Conditions