Sublingual Surprise: A New Variant of Oral Lichen Planus

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Sublingual Surprise: A New Variant of Oral Lichen Planus Xin Jin, DDS, PhD, Ting Hu, DDS, PhD, Xuefeng Zhao, DDS, PhD, Qianming Chen, DDS, PhD, Xin Zeng, DDS, PhD The American Journal of Medicine Volume 127, Issue 1, Pages 28-30 (January 2014) DOI: 10.1016/j.amjmed.2013.10.002 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 The patient had a 2 × 1 cm elevated overgrowth on the right ventral lingual surface (black arrow). It had an overlying pseudomembrane, shallow erosions, and surrounding white reticular striae (white arrows). The American Journal of Medicine 2014 127, 28-30DOI: (10.1016/j.amjmed.2013.10.002) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 2 A biopsy sample was obtained from the overgrowth lesion on the ventral tongue. Pathologic examination showed epithelial hyperparakeratosis, basement layer liquefaction, and a layer of marked lymphocyte infiltrate in the lamina propria immediately underlying the epithelium (hematoxylin and eosin, 4×). The American Journal of Medicine 2014 127, 28-30DOI: (10.1016/j.amjmed.2013.10.002) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 3 Cellular edema, ballooning degeneration, and vacuolization of parts of epithelial and basal cells also were noted (hematoxylin and eosin, 4×). The American Journal of Medicine 2014 127, 28-30DOI: (10.1016/j.amjmed.2013.10.002) Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 4 Treatment with oral pidotimod was followed by intramuscular injection of bacillus Calmette-Guerin polysaccharide nucleic acid. Two months later, the elevated growths had almost disappeared. However white reticular striae still remained (white arrows). The American Journal of Medicine 2014 127, 28-30DOI: (10.1016/j.amjmed.2013.10.002) Copyright © 2014 Elsevier Inc. Terms and Conditions