Selective early increases of bronchoalveolar CD8+ lymphocytes in a LEW rat model of hypersensitivity pneumonitis Hal B. Richerson, MD, J.Daniel Coon,

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Presentation transcript:

Selective early increases of bronchoalveolar CD8+ lymphocytes in a LEW rat model of hypersensitivity pneumonitis Hal B. Richerson, MD, J.Daniel Coon, David Lubaroff, PhD Journal of Allergy and Clinical Immunology Volume 96, Issue 1, Pages 113-121 (July 1995) DOI: 10.1016/S0091-6749(95)70040-4 Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Photomicrographs of representative pulmonary histopathologic conditions from experimental and control LEW rats. A, Section from animal in group A killed 4 hours after initial aerosol challenge with antigen. Small collections of mononuclear cells are seen in area of terminal bronchiole and alveolar ducts and around vessels. (Hematoxylin-eosin stain; original magnification ×80.) B, Section from animal in group B killed 24 hours after initial aerosol challenge with antigen. Localized collections of mononuclear cells are seen in areas of terminal bronchioles, alveolar ducts, alveoli, interstitium, and vessels. (Hematoxylin-eosin stain; original magnification ×80.) C, Section from control animal in group D. No cellular infiltrates are present. (Hematoxylin-eosin stain; original magnification ×80.) Journal of Allergy and Clinical Immunology 1995 96, 113-121DOI: (10.1016/S0091-6749(95)70040-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Photomicrographs of representative pulmonary histopathologic conditions from experimental and control LEW rats. A, Section from animal in group A killed 4 hours after initial aerosol challenge with antigen. Small collections of mononuclear cells are seen in area of terminal bronchiole and alveolar ducts and around vessels. (Hematoxylin-eosin stain; original magnification ×80.) B, Section from animal in group B killed 24 hours after initial aerosol challenge with antigen. Localized collections of mononuclear cells are seen in areas of terminal bronchioles, alveolar ducts, alveoli, interstitium, and vessels. (Hematoxylin-eosin stain; original magnification ×80.) C, Section from control animal in group D. No cellular infiltrates are present. (Hematoxylin-eosin stain; original magnification ×80.) Journal of Allergy and Clinical Immunology 1995 96, 113-121DOI: (10.1016/S0091-6749(95)70040-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Photomicrographs of representative pulmonary histopathologic conditions from experimental and control LEW rats. A, Section from animal in group A killed 4 hours after initial aerosol challenge with antigen. Small collections of mononuclear cells are seen in area of terminal bronchiole and alveolar ducts and around vessels. (Hematoxylin-eosin stain; original magnification ×80.) B, Section from animal in group B killed 24 hours after initial aerosol challenge with antigen. Localized collections of mononuclear cells are seen in areas of terminal bronchioles, alveolar ducts, alveoli, interstitium, and vessels. (Hematoxylin-eosin stain; original magnification ×80.) C, Section from control animal in group D. No cellular infiltrates are present. (Hematoxylin-eosin stain; original magnification ×80.) Journal of Allergy and Clinical Immunology 1995 96, 113-121DOI: (10.1016/S0091-6749(95)70040-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Numbers (A) and percentages (B) of T-cell phenotypes obtained by bronchoalveolar lavage and evaluated by means of flow cytometric analysis. Increases are seen in numbers and shifts in percentages favoring CD8+ phenotypes in experimental groups. An asterisk denotes significant (p < 0.05) difference in experimental group phenotype compared with control numbers or percentages with Tukey's follow-up test. Journal of Allergy and Clinical Immunology 1995 96, 113-121DOI: (10.1016/S0091-6749(95)70040-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Numbers (A) and percentages (B) of T-cell phenotypes obtained by bronchoalveolar lavage and evaluated by means of flow cytometric analysis. Increases are seen in numbers and shifts in percentages favoring CD8+ phenotypes in experimental groups. An asterisk denotes significant (p < 0.05) difference in experimental group phenotype compared with control numbers or percentages with Tukey's follow-up test. Journal of Allergy and Clinical Immunology 1995 96, 113-121DOI: (10.1016/S0091-6749(95)70040-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Numbers (A) and percentages (B) of T-cell phenotypes obtained from minced, previously lavaged lungs and evaluated by means of flow cytometric analysis. Significantly increased percentages, but not numbers, of CD8+ RT6– and CD8+CD45R+ phenotypes are seen in the 24-hour experimental group. An asterisk denotes significant (p < 0.05) difference in experimental group phenotype compared with control numbers or percentages with Tukey's follow-up test. Journal of Allergy and Clinical Immunology 1995 96, 113-121DOI: (10.1016/S0091-6749(95)70040-4) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Numbers (A) and percentages (B) of T-cell phenotypes obtained from minced, previously lavaged lungs and evaluated by means of flow cytometric analysis. Significantly increased percentages, but not numbers, of CD8+ RT6– and CD8+CD45R+ phenotypes are seen in the 24-hour experimental group. An asterisk denotes significant (p < 0.05) difference in experimental group phenotype compared with control numbers or percentages with Tukey's follow-up test. Journal of Allergy and Clinical Immunology 1995 96, 113-121DOI: (10.1016/S0091-6749(95)70040-4) Copyright © 1995 Mosby, Inc. Terms and Conditions