Volume 20, Issue 2, Pages 111-116 (April 2013) Leukocyte infiltration in lung, muscle, and liver after limb compression in rats  Mauricio Wanderley Moral Sgarbi, Bomfim A. Silva, Carmem Maldonado Peres, Tatiana Carolina Alba, Rui Curi, Francisco Garcia Soriano, Daniel Araki Ribeiro, Irineu Tadeu Velasco  Pathophysiology  Volume 20, Issue 2, Pages 111-116 (April 2013) DOI: 10.1016/j.pathophys.2012.12.001 Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Photomicrographs of hind limb crushed muscles (10×) (A) control, not crushed, (B) after 1h release, (C) after 2h release, and (D) after 4h release. Marked edema and muscle fiber necrosis are apparent throughout the time after bandage release. Control muscles (A) have normal architecture and are free of these changes. Pathophysiology 2013 20, 111-116DOI: (10.1016/j.pathophys.2012.12.001) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Changes in myeloperoxidase (MPO) activity in the liver (A), compressed muscle (B) and lungs (C). There was an increased MPO activity within the first 2h in liver and hind limb muscle. MPO activity found in pulmonary tissues increased after 4h. *p<0.05 compared with controls; †p<0.05 compared with controls and 1h. ‡p<0.05 compared with all other groups. Pathophysiology 2013 20, 111-116DOI: (10.1016/j.pathophys.2012.12.001) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Changes in plasma free fatty acids concentrations throughout time after muscle crush injury. Linoleic acid, a poly-unsaturated fatty acid with 2 double carbon bounds, presented a significant decrease in its plasma concentration. EPA: eicosapentoic acid; DHA: decosahexapentoic acid (A). There was an increase in the concentration of saturated free fatty acids in plasma 4h after muscle injury (B). The unsaturated index decreased throughout the experiment (C). *p<0.05; †p<0.01. Pathophysiology 2013 20, 111-116DOI: (10.1016/j.pathophys.2012.12.001) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions