A Phase 2 Study of Allogeneic Mesenchymal Stromal Cells for Luminal Crohn's Disease Refractory to Biologic Therapy Geoffrey M. Forbes, Marian J. Sturm,

Slides:

Advertisements

Similar presentations

Long-term Follow-up Reveals Low Incidence of Colorectal Cancer, but Frequent Need for Resection, Among Australian Patients With Inflammatory Bowel Disease.

Advertisements

The Prevalence and Geographic Distribution of Crohn’s Disease and Ulcerative Colitis in the United States Michael D. Kappelman, Sheryl L. Rifas–Shiman,

The Role of Psychosocial Care in Adapting to Health Care Reform

Abnormal Liver Tests and Fatty Liver on Ultrasound

Thrombocytopenia With Abnormal Liver Function Tests

Ashwin N. Ananthakrishnan, Millie D. Long, Christopher F

Pichamol Jirapinyo, Christopher C. Thompson

Gauree Gupta, Ebbing Lautenbach, James D. Lewis

Celiac Disease and Persistent Symptoms

Lucio Gullo Clinical Gastroenterology and Hepatology

Right Upper Quadrant Pain and a Normal Abdominal Ultrasound

Liver Cirrhosis Is Associated With Venous Thromboembolism Among Hospitalized Patients in a Nationwide US Study Harry Wu, Geoffrey C. Nguyen Clinical.

Rebekah S. Wieland, Richard S. Zubarik, Maryam J. Zenali

Lauren A. Beste, George N. Ioannou, Yin Yang, Michael F

A 31-Year-Old Patient With Colitis and Perianal Disease

Stephen A. Harrison, MD, FACP Clinical Gastroenterology and Hepatology

A 5-Year Prospective Observational Study of the Outcomes of International Treatment Guidelines for Crohn's Disease Garret Cullen, Denise Keegan, Hugh.

Issue Highlights Clinical Gastroenterology and Hepatology

Andree Koop, Michael J. Bartel, Dawn Francis

Should the Reflex Be Reflux

Talya Salz, Robert S. Sandler Clinical Gastroenterology and Hepatology

Miles Basil, Anita Pudusseri, Robert Lowe

Jessica L. Mellinger, Michael L. Volk

Issue Highlights Clinical Gastroenterology and Hepatology

Functional Dyspepsia Is Associated With Sleep Disorders

Activity-Based Costing and Management in a Hospital-Based GI Unit

Endoscopic Therapy for Barrett's Esophagus

Amie L. Harvey, Tommy Yen, Anand Kunda

Millie D. Long, Hans H. Herfarth, Clare A. Pipkin, Carol Q

Leon P. McLean, Jonathan S. Chun, Raymond K. Cross

Francisco A. Sylvester, Scott Leopold, Miriam Lincoln, Jeffrey S

Abnormal Liver Tests and Fatty Liver on Ultrasound

Gastroenterology in a New Era of Accountability: Part 2

New Models of Gastroenterology Practice

Relationship Between Detection of Adenomas by Flexible Sigmoidoscopy and Interval Distal Colorectal Cancer Shari S. Rogal, Paul F. Pinsky, Robert E.

The Iceberg of Celiac Disease: What Is Below the Waterline?

Cannabis Induces a Clinical Response in Patients With Crohn's Disease: A Prospective Placebo-Controlled Study Timna Naftali, Lihi Bar-Lev Schleider,

Issue Highlights Clinical Gastroenterology and Hepatology

David H. Bruining, William J. Sandborn

Najat Mourra, Nikias Colignon Clinical Gastroenterology and Hepatology

Peter Bytzer Clinical Gastroenterology and Hepatology

Patient-Reported Outcomes of Cirrhosis

A Young Woman With Gallstone Pancreatitis and Abnormal Liver Tests: When Is Endoscopic Retrograde Cholangiopancreatography Needed? Andrew D. Rhim, Michael.

Effects of Different Coping Strategies on Physical and Mental Health of Patients With Irritable Bowel Syndrome Lilian Dindo, PhD Clinical Gastroenterology.

Issue Highlights Clinical Gastroenterology and Hepatology

Issue Highlights Clinical Gastroenterology and Hepatology

Issue Highlights Clinical Gastroenterology and Hepatology

Correlation Between the Crohn's Disease Activity and Harvey–Bradshaw Indices in Assessing Crohn's Disease Severity Severine Vermeire, Stefan Schreiber,

Nicolas Williet, William J. Sandborn, Laurent Peyrin–Biroulet

Issue Highlights Clinical Gastroenterology and Hepatology

Thrombocytopenia With Abnormal Liver Function Tests

Palmoplantar Pustulosis and Acrodermatitis in a Patient Treated With Infliximab for Crohn's Sacroiliitis Jürg Wermuth, Fabiola Kind, Michael Steuerwald

A 27-Year-Old Woman With Constipation: Diagnosis and Treatment

Patrick Yachimski, William P. Puricelli, Norman S. Nishioka

Christopher Hung, Desmond Leddin

Coagulation in Liver Disease: A Guide for the Clinician

Issue Highlights Clinical Gastroenterology and Hepatology

Risk of Pancreatitis in Patients With Celiac Disease: Is Autoimmune Pancreatitis a Biologically Plausible Mechanism? John S. Leeds, David S. Sanders

Issue Highlights Clinical Gastroenterology and Hepatology

Coloduodenal Fistula in Crohn’s Disease

Black and White Liver Clinical Gastroenterology and Hepatology

Adverse Outcomes: Why Bad Things Happen to Good People

The Prevalence and Geographic Distribution of Crohn’s Disease and Ulcerative Colitis in the United States Michael D. Kappelman, Sheryl L. Rifas–Shiman,

Medical Therapy for Refractory Pediatric Crohn’s Disease

Issue Highlights Clinical Gastroenterology and Hepatology

M. Babitha Reddy, David M. Poppers, Cora Uram–Tuculescu

Sanjay K. Murthy, E. Jenny Heathcote, Geoffrey C. Nguyen

The Role of Psychosocial Care in Adapting to Health Care Reform

An Unusual Skin Manifestation in a Patient With Ulcerative Colitis

Choosing Wisely and the Perceived Drivers of Endoscopy Use

Presentation transcript:

A Phase 2 Study of Allogeneic Mesenchymal Stromal Cells for Luminal Crohn's Disease Refractory to Biologic Therapy Geoffrey M. Forbes, Marian J. Sturm, Rupert W. Leong, Miles P. Sparrow, Dev Segarajasingam, Adrian G. Cummins, Michael Phillips, Richard P. Herrmann Clinical Gastroenterology and Hepatology Volume 12, Issue 1, Pages 64-71 (January 2014) DOI: 10.1016/j.cgh.2013.06.021 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 Study overview. Clinical Gastroenterology and Hepatology 2014 12, 64-71DOI: (10.1016/j.cgh.2013.06.021) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 CDAI score of 15 subjects at study entry and at day 42. Broken lines indicate patients without clinical response. Clinical Gastroenterology and Hepatology 2014 12, 64-71DOI: (10.1016/j.cgh.2013.06.021) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Mean CDAI by study visit (n = 15). Restricted cubic spline mean regression line with 95% confidence intervals (shaded area). Data points for all patients are shown. Clinical Gastroenterology and Hepatology 2014 12, 64-71DOI: (10.1016/j.cgh.2013.06.021) Copyright © 2014 AGA Institute Terms and Conditions