Clifford H. Van Meter, MD (by invitation), William C

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Presentation transcript:

Myoblast transplantation in the porcine model: A potential technique for myocardial repair Clifford H. Van Meter, MD (by invitation), William C. Claycomb, PhD (by invitation), Joseph B. Delcarpio, PhD (by invitation), Duane M. Smith, PhD (by invitation), Helen deGruiter, RN (by invitation), Frank Smart, MD (by invitation), John L. Ochsner, MD The Journal of Thoracic and Cardiovascular Surgery Volume 110, Issue 5, Pages 1442-1448 (November 1995) DOI: 10.1016/S0022-5223(95)70067-6 Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 1 Injected fetal human atrial cardiomyocytes (HA) are visible as basophilic regions in the left ventricle of the adult pig host (PV). Note the absence of any connective tissue capsule (arrow) and lymphocytes. The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1442-1448DOI: (10.1016/S0022-5223(95)70067-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 2 Injected fetal human atrial cardiomyocytes (HA) also induce what appear to be nascent blood vessels both within the graft and in the interface between graft and host (*).PV, Pig ventricle. Fig. 2 is a higher magnification view of the area demonstrated in Fig. 1. (Hematoxylin and eosin stain; final magnification x 400.) The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1442-1448DOI: (10.1016/S0022-5223(95)70067-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 3 In addition to fetal human atrial cells, fetal human ventricular cardiomyocytes (HV) also survived transplantation. Transplanted HV cells also induced blood vessels (*) in the graft area and host ventricle (*). Graft areas lacked any evidence of rejection as shown by the absence of a connective tissue capsule (arrow) and lymphocytes. (Hematoxylin and eosin stain; final magnification x 400.) The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1442-1448DOI: (10.1016/S0022-5223(95)70067-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 4 In studies in which AT-1 cells were injected into host adult pig left ventricles (PV), clear evidence indicated that injected cardiomyocytes could form nascent adherent junctions (arrow) with the host cardiomyocytes.(Transmission electron micrograph; x 9000.) The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1442-1448DOI: (10.1016/S0022-5223(95)70067-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

Fig. 5 An enlargement of the area shown in Fig. 4 demonstrating the adherent or nascent intercalated disc(arrow) between an adult pig left ventricular cardiomyocyte(PV) and an injected AT-1 cell. (× 33,300.) The Journal of Thoracic and Cardiovascular Surgery 1995 110, 1442-1448DOI: (10.1016/S0022-5223(95)70067-6) Copyright © 1995 Mosby, Inc. Terms and Conditions