Effectiveness of proton pump inhibitors in nonerosive reflux disease

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Effectiveness of proton pump inhibitors in nonerosive reflux disease Bonnie B. Dean, Anacleto D. Gano, Kevin Knight, Joshua J. Ofman, Ronnie Fass  Clinical Gastroenterology and Hepatology  Volume 2, Issue 8, Pages 656-664 (August 2004) DOI: 10.1016/S1542-3565(04)00288-5

Figure 1 Flowchart of the systematic review for NERD and symptomatic GERD. Clinical Gastroenterology and Hepatology 2004 2, 656-664DOI: (10.1016/S1542-3565(04)00288-5)

Figure 2 Treatment comparison with placebo for group 1 (endoscopy negative) patients: pooled difference (treatment − placebo) in proportion with heartburn resolution by time. ▴, Sufficient; ■, complete. Clinical Gastroenterology and Hepatology 2004 2, 656-664DOI: (10.1016/S1542-3565(04)00288-5)

Figure 3 Treatment comparison with placebo for group 2 (negative endoscopy and erythema and friability) patients: pooled difference (treatment − placebo) in proportion with heartburn resolution by time. ▴, Sufficient; ■, complete. Clinical Gastroenterology and Hepatology 2004 2, 656-664DOI: (10.1016/S1542-3565(04)00288-5)

Figure 4 Treatment comparison with placebo for all studies (group 3): pooled difference (treatment − placebo) in proportion with heartburn resolution by time. ▴, Sufficient; ■, complete. Clinical Gastroenterology and Hepatology 2004 2, 656-664DOI: (10.1016/S1542-3565(04)00288-5)