Maternal allo-recognition of the fetus

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Maternal allo-recognition of the fetus Ashley Moffett, M.D., Olympe Chazara, Ph.D., Francesco Colucci, Ph.D. Fertility and Sterility Volume 107, Issue 6, Pages 1269-1272 (June 2017) DOI: 10.1016/j.fertnstert.2017.05.001 Copyright © 2017 Terms and Conditions

Figure 1 Possible interactions between maternal killer immunoglobulin-like receptors (KIR) and fetal human leukocyte antigens (HLA)-C molecules depend on KIR and HLA-C variants respectively present in the mother and fetus. Women can have inhibitory or activating KIR for which there is no HLA-C ligand in the fetus. The genetic combination of a mother with two KIR A haplotypes with a fetus carrying a group C2+HLA-C allele is associated with increased risk of pre-eclampsia. There is a very strong inhibitory signal from a fetal C2+HLA-C when maternal NK cells lack activating KIR (not present on KIR A haplotype). There is a protective effect for pre-eclampsia when a mother has an activating KIR for C2+ HLA-C that is found on KIR B haplotypes. Adapted from Chazara et al. (24). Fertility and Sterility 2017 107, 1269-1272DOI: (10.1016/j.fertnstert.2017.05.001) Copyright © 2017 Terms and Conditions