Loss of tumor cell CCR4 expression upon leukemic change in adult T-cell leukemia/lymphoma Kazunari Sugita, MD, Takatoshi Shimauchi, MD, Rieko Kabashima,

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Loss of tumor cell CCR4 expression upon leukemic change in adult T-cell leukemia/lymphoma Kazunari Sugita, MD, Takatoshi Shimauchi, MD, Rieko Kabashima, MD, Daiki Nakashima, MD, Ryosuke Hino, MD, Kenji Kabashima, MD, Motonobu Nakamura, MD, Yoshiki Tokura, MD Journal of the American Academy of Dermatology Volume 61, Issue 1, Pages 163-164 (July 2009) DOI: 10.1016/j.jaad.2008.10.008 Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Initial presentation in January 2006. B, Histology of the skin tumor. C, Immunohistochemical staining for CD4. D, Recurrent tumors in August 2007. E, Splenic involvement with tumor cells (September 2007). (B and E, Hematoxylin–eosin stain; original magnification: B, C, and E, ×200.) Journal of the American Academy of Dermatology 2009 61, 163-164DOI: (10.1016/j.jaad.2008.10.008) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A and B, Flow cytometry of peripheral blood mononuclear cells and tumor-infiltrating cells during the nonleukemic phase in January 2006. C, Peripheral blood mononuclear cells and subcutaneous and spleen cells (D) after the leukemic conversion in September 2007. They were double-stained with the indicated monoclonal antibodies. Journal of the American Academy of Dermatology 2009 61, 163-164DOI: (10.1016/j.jaad.2008.10.008) Copyright © 2008 American Academy of Dermatology, Inc. Terms and Conditions