Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sézary syndrome Alexander Kreuter, MD, Peter Altmeyer, MD

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Rapid onset of CD8+ aggressive T-cell lymphoma during bexarotene therapy in a patient with Sézary syndrome Alexander Kreuter, MD, Peter Altmeyer, MD Journal of the American Academy of Dermatology Volume 53, Issue 6, Pages 1093-1095 (December 2005) DOI: 10.1016/j.jaad.2005.06.044 Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Immunohistologic stainings at first presentation (CD4+ cells, 80% positive [A]; CD8+ cells, 10% positive [B]). Immunohistologic transformation after 6 months of bexarotene therapy (CD4+ cells, 0% positive [C]; CD8+ cells, 90% positive [D]). (A and C, CD4 stain, original magnification ×40; B and D, CD8 stain, original magnification ×40.) Journal of the American Academy of Dermatology 2005 53, 1093-1095DOI: (10.1016/j.jaad.2005.06.044) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Rapid onset of subcutaneous tumors (tumor masses filling complete left cheek [A]; multiple nodules, 1-5 cm in diameter, mostly located on back and chest [B]). Journal of the American Academy of Dermatology 2005 53, 1093-1095DOI: (10.1016/j.jaad.2005.06.044) Copyright © 2005 American Academy of Dermatology, Inc. Terms and Conditions