Resolvins RvD1 and 17(R)-RvD1 alleviate signs of inflammation in a rat model of endometriosis  Natalia Dmitrieva, Ph.D., Gregory Suess, B.S., Russell Shirley, B.S.  Fertility and Sterility  Volume 102, Issue 4, Pages 1191-1196 (October 2014) DOI: 10.1016/j.fertnstert.2014.06.046 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Effects of a single injection of RvD1 (A, IV) or Rt-RvD1 (B, IP) on EB extravasation in endometrial cysts. The inset in (A) shows one cyst from a rat treated with vehicle (left) and another cyst from a rat treated with RvD1 (right). Note the presence of the dark blue dye in the cyst vascular bed of the vehicle-treated rat; the color of the cyst treated with RvD1 is lighter because the level of the dye is lower. ∗P<.05, ∗∗P<.01 compared with vehicle. Fertility and Sterility 2014 102, 1191-1196DOI: (10.1016/j.fertnstert.2014.06.046) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Effect of a single IP injection of 900 ng/kg Rt-RvD1 on severity of vaginal hyperalgesia. (A) Individual records of VMR response (upper trace of each panel) to vaginal distention (lower trace of each panel) of one rat after vehicle and Rt-RvD1. Arrowheads indicate the VMR threshold. (B) Average VMR threshold measured after vehicle, Rt-RvD1, and 4 to 5 days after treatment (on the next proestrous day after treatment). ∗P<.05 compared with vehicle or baseline. Fertility and Sterility 2014 102, 1191-1196DOI: (10.1016/j.fertnstert.2014.06.046) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions