Yuto Otani, PhD, Yasuhiko Tabata, PhD, Yoshito Ikada, PhD

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Presentation transcript:

Sealing effect of rapidly curable gelatin-poly (l-glutamic acid) hydrogel glue on lung air leak Yuto Otani, PhD, Yasuhiko Tabata, PhD, Yoshito Ikada, PhD The Annals of Thoracic Surgery Volume 67, Issue 4, Pages 922-926 (April 1999) DOI: 10.1016/S0003-4975(99)00153-8

Fig 1 The sealing effect of gelatin-poly(l-glutamic acid) (PLGA) hydrogel glue on the air leak of rat lung wound as a function of poly(l-glutamic acid) concentration. The concentration of gelatin and water-soluble carbodiimide was 100 and 9.59 mg/mL, respectively. The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10.1016/S0003-4975(99)00153-8)

Fig 2 The urea effect on the air leak of rat lung wound sealed with the gelatin-poly(l-glutamic acid) hydrogel glue containing urea. The concentration of gelatin, poly(l-glutamic acid), and water-soluble carbodiimide was 100, 100, and 9.59 mg/mL, respectively. The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10.1016/S0003-4975(99)00153-8)

Fig 3 The water-soluble carbodiimide (WSC) effect on the air leak of rat lung wound sealed with the gelatin-poly(l-glutamic acid) hydrogel glue with (open circle) and without urea (open triangle). The concentration of gelatin, poly(l-glutamic acid), and urea was all 100 mg/mL. The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10.1016/S0003-4975(99)00153-8)

Fig 4 The rat lung wound appearance 1 minute after application of the gelatin-poly(l-glutamic acid) hydrogel glue with (A) and without urea (B), and the fibrin glue (C). Both the hydrogel glues adhered firmly to the lung surface, whereas the fibrin glue did not. The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10.1016/S0003-4975(99)00153-8)

Fig 5 Histologic sections of rat lung tissue after application of the gelatin-poly(l-glutamic acid) (PLGA) hydrogel glue with (A) and without urea (B), the fibrin glue (C), and before glue application (D). (hematoxylin and eosin staining; optical magnification, ×70.) The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10.1016/S0003-4975(99)00153-8)

The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10 The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10.1016/S0003-4975(99)00153-8)

The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10 The Annals of Thoracic Surgery 1999 67, 922-926DOI: (10.1016/S0003-4975(99)00153-8)