Why We Should Put Clothes on Mice Irfan J. Lodhi, Clay F. Semenkovich  Cell Metabolism  Volume 9, Issue 2, Pages 111-112 (February 2009) DOI: 10.1016/j.cmet.2009.01.004 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 UCP1 Deficiency and Thermoneutrality UCP1 knockout mice maintained at room temperature (top panel in blue to represent a cold environment) activate UCP1-independent processes to maintain body temperature, an effect that obscures the role of UCP1 in bioenergetics. The same mice maintained at thermoneutrality (bottom panel in red to represent a warm environment) do not activate these processes and are susceptible to the development of obesity. Cell Metabolism 2009 9, 111-112DOI: (10.1016/j.cmet.2009.01.004) Copyright © 2009 Elsevier Inc. Terms and Conditions