Volume 372, Issue 9652, Pages (November 2008)

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Volume 372, Issue 9652, Pages 1828-1834 (November 2008) Association between the SERPING1 gene and age-related macular degeneration: a two-stage case–control study Sarah Ennis, PhD, Catherine Jomary, PhD, Robert Mullins, PhD, Angela Cree, BSc, Xiaoli Chen, MSc, Alex MacLeod, FRCOphth, Stephen Jones, PhD, Prof Andrew Collins, PhD, Prof Edwin Stone, PhD, Prof Andrew Lotery, FRCOphth The Lancet Volume 372, Issue 9652, Pages 1828-1834 (November 2008) DOI: 10.1016/S0140-6736(08)61348-3 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 1 Association across SERPING1 region with age-related macular degeneration The x-axis shows the relative positions of the 11 single nucleotide polymorphisms (SNPs) genotyped in the UK sample using the University of California Santa Cruz, March, 2006, reference sequence (NCBI build 36.1). The green diamond represents rs2511989, which was genotyped in both the original scan and the follow-up scan. The blue squares depict SNPs genotyped in the initial candidate gene scan. The red dots depict the SNPs that were typed in the follow-up scan only. The probability threshold for significance Bonferroni corrected for the 93 SNPs genotyped in the initial scan plus the eight additional SNPs genotyped in the follow-up is represented by a dashed green line. The y-axis shows the negative natural log of the p value for association using the Cochrane-Armitage test. The SERPING1 gene is drawn to scale and shows all eight exons. Exon one is untranslated (red bars), whereas exons two and eight are partially translated. Exons three to seven are translated (blue bars). The Lancet 2008 372, 1828-1834DOI: (10.1016/S0140-6736(08)61348-3) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 2 Expression analysis with RT-PCR showing amplification of complementary DNA for SERPING1 in both neural retina (RET) and RPE-choroidal tissues (RPE/CH) No product was amplified from either tissue when the reverse transcription step was omitted (−rt). The Lancet 2008 372, 1828-1834DOI: (10.1016/S0140-6736(08)61348-3) Copyright © 2008 Elsevier Ltd Terms and Conditions