Chemical-Induced Naive Pluripotency Angela J. Russell, Laurence Silpa  Cell Chemical Biology  Volume 23, Issue 5, Pages 532-534 (May 2016) DOI: 10.1016/j.chembiol.2016.05.002 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Production of Embryonic and Epiblast Stem Cells. Naive pluripotent mouse ESCs and primed pluripotent mouse EpiSCs can be derived from pre-implantation blastocysts and post-implantation epiblasts, respectively. Both pluripotent cell types have, in principle, the capacity to differentiate to cells representative of the three primary germ layers and ultimately into the cell types in embryonic and adult tissues. Epiblastin A, a recently discovered CK1 inhibitor, was found to reprogram mouse EpiSCs refractory to other treatments to a naive pluripotent state. Cell Chemical Biology 2016 23, 532-534DOI: (10.1016/j.chembiol.2016.05.002) Copyright © 2016 Elsevier Ltd Terms and Conditions