Model of human CLC-Kb transporter topology and positions of amino acid exchanges due to mutations in the CLCNKB gene as identified in Bartter syndrome.

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Model of human CLC-Kb transporter topology and positions of amino acid exchanges due to mutations in the CLCNKB gene as identified in Bartter syndrome patients. Model of human CLC-Kb transporter topology and positions of amino acid exchanges due to mutations in the CLCNKB gene as identified in Bartter syndrome patients. Putative transmembranous α-helical domains are numbered (1 to 13). Amino acids are represented by gray or white circles with amino acid numbering given at intervals in white circles. Amino acid exchanges are shown using the standard notation. MARTIN KONRAD et al. JASN 2000;11:1449-1459 ©2000 by American Society of Nephrology