Role of Blood Supply Nutrition to parenchyma (brain cells).

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Presentation transcript:

Role of Blood Supply Nutrition to parenchyma (brain cells). Brain is completely dependent on oxygen supply - No O2 reserves. Irreversible damage in 4-6 minutes if no oxygen Brain requires 20% of O2 for 2% of body weight. Brain requires glucose for energy No ability to use fat Remove carbon dioxide and waste-products from cells Cerebral perfusion > 60 ml/100gr min-1 in Gray matter 40 < X < 60 in White matter 750mL blood pumped per minute and circulated blood returned for reoxygenation

Network of arteries and veins Vascular Network Network of arteries and veins Arteries carry blood away from the heart Arteries divide into smaller vessels called: arterioles Arterioles divide further into capillaries Vascular Network Veins carry blood toward the heart Smallest level are venules that are connected to capillaries Venules Carry blood to sinuses on cortical surface

Local blood flow Arteries Arterioles Capillaries Venules Sinuses

Cerebrovascular Supply Two Systems Carotid System Vertebral Basilar System Meet in Circle of Willis

Vertebral / Basilar Arteries Brain stem Basilar Artery Vertebral Arteries

Vertebral Basilar System Two Vertebral Arteries enter skull through Foramen Magnum Join to form the Basilar Artery and then Circle of Willis Numerous small branches Supplies the brainstem and cerebellum Posterior Inferior Cerebellar Artery (PICA) is one that serves cerebellum.

Carotid Arteries

Carotid System Common Carotid Artery Divides into two branches External Branch Supply blood to facial muscles, forehead and oral, nasal and orbital cavities Internal Branch (enters the skull through the carotid foramen) Anterior choroidal artery (supplies optic tract, posterior limb of internal capsule, branches to midbrain,and lateral geniculate nucleus). Ophthalmic artery (Supplies blood to the eyeball and ocular muscles) Major source of blood to the brain After joining Circle of Willis becomes anterior cerebral and middle cerebral arteries

Circle of Willis

Wreath-shaped circle of Willis located at ventral surface of brain Connects Carotid and Vertebral Basilar Systems Middle and Anterior Cerebral Arteries Anterior Communicating Artery Posterior Cerebral Artery Posterior Communicating Artery

Cortical Blood Supply ACA: Medial Frontal Perfusion MCA: Lateral Perfusion PCA: Posterior medial Perfusion, cerebellum Watershed Areas: overlap between major arteries Major Arteries  Carotid  Anterior Cerebral  Middle Cerebral Posterior Cerebral

Cortical (Circumferential) Branches Central (Penetrating) Branches Two Types of Arteries Cortical (Circumferential) Branches Supply External Brain Structures Central (Penetrating) Branches Small Penetrate ventral surface to supply internal brain structures

Anterior Cerebral Artery Supplies Orbital and Medial Surfaces of Frontal and Parietal Lobes Interruption causes Cortical Arteries Paralysis of legs and feet Difficulty in prefrontal lobe functions of cognitive thinking, judgment, motor initiation and self monitoring

Middle Cerebral Artery Direct continuation of carotid artery Cortical Branches Temporal Parietal Frontal

MCA: Cortical Branches Supplies blood to entire lateral surface of brain Somatosensory Cortex Motor Cortex Broca's Area Heschl’s Gyrus Wernicke’s Area Therefore, symptoms include Aphasia Motor deficits Neglect (right hemisphere)

MCA – Penetrating Arteries Supplies basal ganglia and diencephalon Interruption causes Contralateral hemiplegia Impaired sensory systems Touch Pain and temperature

Central Penetrating Arteries Arise from cortical arteries or from Circle of Willis Penetrate inferior surface of brain Can form channels to facilitate blood supply Central (Penetrating) Arteries Supply Thalamus Hypothalamus Basal Ganglia Internal capsule Choroid Plexus

Posterior Cerebral Artery Supplies blood to anterior and inferior temporal lobes, uncus, inferior temporal gyri, inferior and medial occipital lobe Watersheds with middle cerebral artery Interruption causes Homonymous hemianopsia Possible total blindness Cerebellar symptoms

Collateral Circulation Redundant arteries provide alternative supply when primary supply is lost Small, normally closed arteries open up after occlusion, connecting two larger arteries or different parts of the same artery. Dependent on location and severity of blockage Better collateral circulation if blockage is near main trunk Better if blockage occurs gradually

Hemorrhagic (Bleed). 20% of strokes are due to arteries rupturing. Vascular Pathologies Occlusive (Something is blocked causing ischemia). 80% of strokes are ischemic Embolism: object from another part of the body which travels through artery until it gets stuck. Thrombosis: object originating within a blood vessel: local buildup of fatty substances usually at a bifurcation of artery, these can rupture leading to catastrophic blockage Hemorrhagic (Bleed). 20% of strokes are due to arteries rupturing.

Risk factor for ischemic stroke Atherosclerosis from reduced lumen due to lipids, calcium fatty particles etc. (‘Athera’ = porridge in Greek) A form of Arteriosclerosis: a general term describing any hardening (and loss of elasticity) of arteries. Leads to stenosis (narrowing) of the artery, gradually leading to insufficient blood supply Plaques can rupture, creating a thrombus in blood supply

Vascular Pathologies - Bleeds Hemorrhagic Bleeding from ruptured vessels Types Intracerebral: More common in thalamus and basal ganglia Subdural Aneurysm Aneurysm

Haemorrhages 20% of strokes are bleeds Typically, due to ruptured aneurysm An aneurysm is a sac-like protrusion of an artery caused by a weakened area within the vessel wall. Introspectively, the worst headache of your life. http://www.microvent.com/ Surgery to clip aneurysm can save patients life. CT of recent haemorrhage

Arteriovenous Malformations AVMs can cause hemorrhagic strokes Tangled web of arteries and veins present since birth

Blood returns to lungs for oxygen Drain into Sinus System Venous Sinus System Blood returns to lungs for oxygen Drain into Sinus System Dural Sinuses Superior Sagittal Sinus Inferior Sagittal Sinus Straight Sinus Transverse Sinus Cavernous Sinus Petrosal Sinuses

Notes Regulation of Cerebral Blood Flow Blood-Brain Barrier Closed system under constant pressure Controlled by elasticity of blood vessels, and metabolic needs Aging can cause less elasticity responsiveness and eveness of flow Blood-Brain Barrier Tight system does not allow direct contact of all brain tissues with blood Specialized system to extract needed molecules May impede medicine entering the brain