Hypertensive mechanisms of fructose Hypertensive mechanisms of fructose.23 Arrows represent direct effects, or indirect effects through intermediates, which is not shown for simplicity. Hypertensive mechanisms of fructose.23 Arrows represent direct effects, or indirect effects through intermediates, which is not shown for simplicity. NO, nitric oxide; RAS, renin-angiotensin system; RNS, reactive nitrogen species; ROS, reactive oxygen species.23 James J DiNicolantonio, and Sean C Lucan Open Heart 2014;1:e000167 ©2014 by British Cardiovascular Society