Minimum clinically important difference for the COPD Assessment Test: a prospective analysis Dr Samantha S C Kon, MBBS, Jane L Canavan, PhD, Sarah E.

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Minimum clinically important difference for the COPD Assessment Test: a prospective analysis Dr Samantha S C Kon, MBBS, Jane L Canavan, PhD, Sarah E Jones, MSc, Claire M Nolan, BSc, Amy L Clark, BSc, Mandy J Dickson, RGN, Brigitte M Haselden, PhD, Prof Michael I Polkey, PhD, William D-C Man, PhD The Lancet Respiratory Medicine Volume 2, Issue 3, Pages 195-203 (March 2014) DOI: 10.1016/S2213-2600(14)70001-3 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Association between change in CAT score and change in (A) SGRQ score and (B) CRQ score with pulmonary rehabilitation (Study 1) CAT=COPD Assessment Test. SGRQ=St George's Respiratory Questionnaire. CRQ=Chronic Respiratory Questionnaire. The Lancet Respiratory Medicine 2014 2, 195-203DOI: (10.1016/S2213-2600(14)70001-3) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Receiver operator characteristic curves using a change in COPD Assessment Test score of −2 to best predict achievement of minimum clinically important improvement in (A) SGRQ score and (B) CRQ score (Study 1) ΔSGRQ=change in St George's Respiratory Questionnaire score. ΔCRQ=change in Chronic Respiratory Questionnaire score. AUC=area under the curve C statistic. The Lancet Respiratory Medicine 2014 2, 195-203DOI: (10.1016/S2213-2600(14)70001-3) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 3 Association between CAT score and change in SGRQ score at hospital discharge for acute exacerbation of COPD to 90 days after discharge (Study 2) CAT=COPD Assessment Test. SGRQ=St George's Respiratory Questionnaire. The Lancet Respiratory Medicine 2014 2, 195-203DOI: (10.1016/S2213-2600(14)70001-3) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 4 Association between change in CAT score and change in SGRQ score over 12 months in stable patients with COPD (Study 3) CAT=COPD Assessment Test. SGRQ=St George's Respiratory Questionnaire. The Lancet Respiratory Medicine 2014 2, 195-203DOI: (10.1016/S2213-2600(14)70001-3) Copyright © 2014 Elsevier Ltd Terms and Conditions