Hantavirus infections T. Avšič-Županc, A. Saksida, M. Korva  Clinical Microbiology and Infection  DOI: 10.1111/1469-0691.12291 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 Hantavirus life cycle and spillover infection to humans. In nature hantaviruses are circulating via horizontal transmission between chronically infected natural host reservoirs (mice, rats, voles). Most human infections occur when contaminated aerosolized rodent excreta are inhaled. Clinical Microbiology and Infection DOI: (10.1111/1469-0691.12291) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 Schematic representation of hantavirus infection kinetics with a clinical course of the disease in humans. A typical course of haemorrhagic fever with renal syndrome (HFRS) can be divided into five distinct phases: febrile, hypotensive, oliguric, polyuric and convalescent. After the infection viral load starts to peak and with the onset of the first clinical symptoms, the antibodies rise. Hallmark laboratory findings that are substantial with development of HFRS are decreases in platelets and urine output and increase in serum creatinine level. Clinical Microbiology and Infection DOI: (10.1111/1469-0691.12291) Copyright © 2015 The Authors Terms and Conditions