Steven A. McCarroll, Steven E. Hyman Neuron

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Progress in the Genetics of Polygenic Brain Disorders: Significant New Challenges for Neurobiology Steven A. McCarroll, Steven E. Hyman Neuron Volume 80, Issue 3, Pages 578-587 (October 2013) DOI: 10.1016/j.neuron.2013.10.046 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Different Kinds of Genetic Variation and Different Approaches to Genetic Analysis Are Influenced by Human Population History (A) Humans have an eccentric population history, in which small, ancestral populations rapidly expanded into a population of some seven billion individuals. (B) Genetic variants that have arisen recently in human history, including new mutations, are generally ascertained by genome sequencing. (C) Polymorphisms that were already present in the small, ancestral populations can be systematically evaluated for relationship to phenotypes, on thousands of genetic backgrounds, using inexpensive array-based assay platforms. Neuron 2013 80, 578-587DOI: (10.1016/j.neuron.2013.10.046) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Emerging Genetic Evidence on Complex Brain Disorders Converges on Specific Molecular Complexes (A) Multiple subunits of voltage-gated calcium channels are among the genome’s strongest associations to schizophrenia and bipolar disorder. (B) Genes encoding the postsynaptic components of excitatory synapses are implicated by both rare and common variants in schizophrenia. Neuron 2013 80, 578-587DOI: (10.1016/j.neuron.2013.10.046) Copyright © 2013 Elsevier Inc. Terms and Conditions