Hyperoxia for management of acid-base status during deep hypothermia with circulatory arrest Jeffrey M Pearl, MD, Donald W Thomas, Gary Grist, Jodie.

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Hyperoxia for management of acid-base status during deep hypothermia with circulatory arrest Jeffrey M Pearl, MD, Donald W Thomas, Gary Grist, Jodie Y Duffy, PhD, Peter B Manning, MD The Annals of Thoracic Surgery Volume 70, Issue 3, Pages 751-755 (September 2000) DOI: 10.1016/S0003-4975(00)01656-8

Fig 1 pH values of patients who had α-stat or pH-stat strategies. Only patients in group IV (pH stat and hyperoxia) had a normal pH after deep hypothermic circulatory arrest. Group IV had a greater pH after deep hypothermic circulatory arrest than any of the other three groups, indicating less acid generation. (∗p < 0.05 compared with groups I through III.) The Annals of Thoracic Surgery 2000 70, 751-755DOI: (10.1016/S0003-4975(00)01656-8)

Fig 2 Base excess values of patients who had α-stat or pH-stat strategies. The base excess, measured after deep hypothermic circulatory arrest, was lower in the pH-stat and hyperoxia patients (group IV) than in any other group. This correlated with a pH after deep hypothermic circulatory arrest within normal range. (∗p < 0.05 compared with groups I through III.) The Annals of Thoracic Surgery 2000 70, 751-755DOI: (10.1016/S0003-4975(00)01656-8)

Fig 3 Acid production corrected for the time of circulatory arrest in normoxic and hyperoxic patients. Patients treated with hyperoxia before deep hypothermic circulatory arrest had less acid generation during deep hypothermic circulatory arrest than their respective normoxic cohorts. Patients in group IV (pH-stat and hyperoxia) had only 25% as much acid generation during 60 minutes of bypass than the next closest group. (∗p < 0.05 compared with groups I through III.) The Annals of Thoracic Surgery 2000 70, 751-755DOI: (10.1016/S0003-4975(00)01656-8)