Shannon Otsuka, BSc, Gwyn Bebb, BMBCh, PhD, FRCPC

Slides:

Advertisements

Similar presentations

Primary Small Cell Carcinoma of the Esophagus Jima Lv, MD, Jun Liang, MD, Jinwan Wang, MD, Luhua Wang, MD, Jie He, MD, Zefen Xiao, MD, Weibo Yin, MD Journal.

Advertisements

Epidermal growth factor receptor tyrosine kinase inhibitors as initial therapy for non- small cell lung cancer: Focus on epidermal growth factor receptor.

Silvestri Gerard A. , MD, FCCP, Rivera M. Patricia , MD, FCCP CHEST

Carcinoma NOS is a Common Histologic Diagnosis and is Increasing in Proportion Among Non-small Cell Lung Cancer Histologies Sai-Hong Ignatius Ou, MD,

Volume 7, Issue 3, Pages (March 2005)

SC17.02 Lung Cancer in China: Challenges and Perspectives

ALK FISH and IHC: You Cannot Have One without the Other

Urokinase-induced smooth muscle cell responses require distinct signaling pathways: A role for the epidermal growth factor receptor Suzanne M. Nicholl,

Signaling molecules as therapeutic targets in allergic diseases

Tumor necrosis factor: Biology and therapeutic inhibitors

Chasing Therapeutic Targets in Thymic Malignancies: Finding Needles in the Haystack to Frame a Comprehensive Canvas? Nicolas Girard, MD Journal of Thoracic.

Outcomes of Second-Line Chemotherapy in Patients with Relapsed Extensive Small Cell Lung Cancer Sandra Froeschl, MD, Garth Nicholas, MD, FRCPC, Victor.

Personalizing Therapy for Colorectal Cancer

Targeting ROS1 with Anaplastic Lymphoma Kinase Inhibitors: A Promising Therapeutic Strategy for a Newly Defined Molecular Subset of Non–Small-Cell Lung.

Axl Receptor Axis: A New Therapeutic Target in Lung Cancer

Rebecca Muirhead, MBChB, MRCP, Stuart G

Chadrick E. Denlinger, MD, John S. Ikonomidis, MD, PhD, Carolyn E

Personalizing Therapy for Colorectal Cancer

A Radical Role for p38 MAPK in Tumor Initiation

OPG/RANKL/RANK Pathway as a Therapeutic Target in Cancer

Development of PI3K/AKT/mTOR Pathway Inhibitors and Their Application in Personalized Therapy for Non–Small-Cell Lung Cancer Vassiliki Papadimitrakopoulou,

Theresa A. Reno, PhD, Jae Y. Kim, MD, Dan J. Raz, MD

Inflammation, Epithelial to Mesenchymal Transition, and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance Kostyantyn Krysan, PhD,

Electronic Updates for JTO Readers

Hedgehog Signaling Pathway and Lung Cancer

A. Craig Lockhart, Mace L. Rothenberg, Jordan D. Berlin

TGF-² Signaling Pathway in Lung Adenocarcinoma Invasion

The International Association for the Study of Lung Cancer International Staging Project on Lung Cancer Peter Goldstraw, MB, FRCS, John J. Crowley, PhD

The Thymus and the Immune System: Layered Levels of Control

BRAF Alterations as Therapeutic Targets in Non–Small-Cell Lung Cancer

Vascular Endothelial Growth Factor (VEGF) Pathway

Olga C. J. Schuurbiers, MD, Johannes H. A. M

A Case of Invasive Mucinous Pulmonary Adenocarcinoma with a CD74-NRG1 Fusion Protein Targeted with Afatinib Parneet K. Cheema, MD, MBiotech, FRCPC Journal.

LKB1 Regulated Pathways in Lung Cancer Invasion and Metastasis

Inflammatory health effects of indoor and outdoor particulate matter

Chemokines and leukocyte trafficking in rheumatoid arthritis

Intratumoral Lymphatic Vessel Involvement is an Invasive Indicator of Completely Resected Pathologic Stage I Non-small Cell Lung Cancer Masahiko Harada,

Hypoxia: Signaling the Metastatic Cascade

Current understanding of stem cell mobilization

Is iNOS Beginning to Smoke?

Erratum Journal of Thoracic Oncology

Anoor Paripati, MBBS, Chris Kingsley, PhD, Glen J. Weiss, MD

Chemokines in the Biology of Lung Cancer

SRC and STAT Pathways Journal of Thoracic Oncology

Yan Feng, MD, Praveena S. Thiagarajan, PhD, Patrick C. Ma, MD

Mitotic Inhibitors Journal of Thoracic Oncology

A Translational View of the Molecular Pathogenesis of Lung Cancer

CXCR4 Overexpression Is Associated with Poor Outcome in Females Diagnosed with Stage IV Non-small Cell Lung Cancer Shannon Otsuka, MSc, Alexander C.

Mirror Mirror on the Wall, Who Is the Fairest of Them All

Trends in Stage Distribution for Patients with Non-small Cell Lung Cancer: A National Cancer Database Survey Daniel Morgensztern, MD, Shean Huey Ng,

Newly Discovered Olfactory Receptors in Epidermal Keratinocytes Are Associated with Proliferation, Migration, and Re-Epithelialization of Keratinocytes

Benjamin Solomon, MBBS, PhD, Richard B. Pearson, PhD

Jair Bar, MD, PhD, Glenwood D. Goss, MD, FCPSA, FRCPC

Edar Signaling in the Control of Hair Follicle Development

Jie Huang, Juan Peng, Linlang Guo, MD, PhD

The Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Lung Cancer: Still Following the Right TRAIL? Emmet E. McGrath, MB, PhD Journal of Thoracic.

Recursive Partitioning Analysis Groups II–III Brain Metastases of Non-small Cell Lung Cancer: A Phase II Randomized Study Comparing Two Concurrent Chemoradiotherapy.

Florian E. Togel, Christof Westenfelder

Genetic Changes in Squamous Cell Lung Cancer: A Review

Ethnic Differences in the Management of Lung Cancer in New Zealand

European Lung Cancer Conference (ELCC) 2016 Organisation

Molecular Characterization of Acquired Resistance to the BRAF Inhibitor Dabrafenib in a Patient with BRAF-Mutant Non–Small-Cell Lung Cancer Charles M.

Regina M. Vidaver, PhD, Beth S. Schachter, PhD

The new kid on the block(ade) of the IGF-1 receptor

Christina S. Baik, MD, MPH, Marc C. Chamberlain, MD, Laura Q. Chow, MD

Tumor necrosis factor: Biology and therapeutic inhibitors

ALK Gene Rearrangements: A New Therapeutic Target in a Molecularly Defined Subset of Non-small Cell Lung Cancer Benjamin Solomon, MBBS, PhD, Marileila.

A Review of First-Line Treatment for Small-cell Lung Cancer

Mark A. Socinski, MD Journal of Thoracic Oncology

Role of the Wnt Signaling Pathway and Lung Cancer

Presentation transcript:

The CXCR4/SDF-1 Chemokine Receptor Axis: A New Target Therapeutic for Non-small Cell Lung Cancer Shannon Otsuka, BSc, Gwyn Bebb, BMBCh, PhD, FRCPC Journal of Thoracic Oncology Volume 3, Issue 12, Pages 1379-1383 (December 2008) DOI: 10.1097/JTO.0b013e31818dda9d Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Schematic illustrating molecular pathways by which CXCR4 acts. Stromal cell derived factor (SDF-1) bound-CXCR4, possibly after incorporation into lipid rafts, acts via Gαi, to activate the phosphoinositol-3-kinase (PI3K) and mitogen activated protein kinase (MAPK) signaling pathways. Activated CXCR4 increases intracellular calcium mobilization and induces phosphorylation of focal adhesion components such as FAK and Pyk2. The activated signal transduction pathways contribute to chemotaxis, cell migration, and secretion of various matrix metalloproteinases (MMP's) including MMP-2 and MMP-9. Supporting references in brackets. Journal of Thoracic Oncology 2008 3, 1379-1383DOI: (10.1097/JTO.0b013e31818dda9d) Copyright © 2008 International Association for the Study of Lung Cancer Terms and Conditions