Cortical Processing: How Mice Predict the Visual Effects of Locomotion Marina Fridman, Leopoldo Petreanu  Current Biology  Volume 27, Issue 23, Pages R1272-R1274 (December 2017) DOI: 10.1016/j.cub.2017.10.038 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Testing for predictive signals in mouse cortical circuits. (A) Predictive coding theories posit that neurons compare predictions with incoming sensory information in a subtractive manner to signal prediction errors. (B) Virtual reality setup used by Leinweber et al. [1]. A head-fixed mouse runs on a floating ball while watching a screen. The visual flow on the screen is matched to his running speed and direction. (C) Summary of expected activity for A24b/M2 inputs in V1 under the hypotheses that predictions are sent in motor or visual coordinates. With normal visuomotor coupling it is impossible to distinguish the two hypotheses. However, in the inverted visuomotor coupling the left turn of the mouse is coupled to the visual flow usually associated with a right turn. In this case a motor signal can be distinghuished from one predicting visual flow. Current Biology 2017 27, R1272-R1274DOI: (10.1016/j.cub.2017.10.038) Copyright © 2017 Elsevier Ltd Terms and Conditions