B A D C * * E F Panc-1 cells Figure S1 DNA ladder h

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B A D C * * E F Panc-1 cells Figure S1 DNA ladder 0 2.5 5 10 20 48 h 0 2.5 5 10 20 48 h Mw YM155 (nM) Mw: DNA 100bp Plus maker A Control YM155 (10 nM) Panc-1 cells C D %Cells with apoptotic nuclei 12 Time (h) * 24 36 48 %Cells with apoptotic nuclei YM155 (nM) * 5 10 20 E 0 5 10 20 Cleaved Caspase 8 Cleaved PARP Bid tBid β-actin YM155 (nM) 48 h Caspase 9 Cleaved Caspase 3 F YM155(10 nM) 0 12 24 36 48 Time (h) Cleaved Caspase 8 Cleaved PARP Bid tBid β-actin Caspase 9 Cleaved Caspase 3

A B Figure S2 Control YM155 (10 nM) PC-3 PC-3 YM155 (nM) 0 5 10 20 survivin 0 5 10 20 PC-3 DR5 β-actin