Tertiary lymphoid organs in recalcitrant chronic rhinosinusitis

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Tertiary lymphoid organs in recalcitrant chronic rhinosinusitis Aden Lau, MBiB, BSc, Susan Lester, BSc (Hons), Sophia Moraitis, BSc, Judy Ou, MBBS, BSc, Alkis J. Psaltis, MBBS (Hons), PhD, FRACS, Shaun McColl, PhD, DSc, FFSc, RCPA, Maureen Rischmueller, MBBS, FRACP, Peter-John Wormald, MD, FRACS, Sarah Vreugde, MD, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 4, Pages 1371-1373.e6 (April 2017) DOI: 10.1016/j.jaci.2016.08.052 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Relative expression of differentially expressed TLO-related genes in CRSsNP and CRSwNP tissue. Genes are grouped according to function into lymphocyte homing and compartmentalization (A), GC reaction and T-cell regulation (B), lymphangiogenesis and white blood cell recruitment (C), and lymph node development (D). Y-axes are plotted in log-2 scale. Error bars indicate the 95% CIs. *P ≤ .05, **P < .01, and ***P < .001. Journal of Allergy and Clinical Immunology 2017 139, 1371-1373.e6DOI: (10.1016/j.jaci.2016.08.052) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Representative images of TLOs in patients with CRSwNP. A, Hematoxylin and eosin staining showing a TLO (red circle) and tissue eosinophilia (black arrows in inlet). B, A highly organized TLO containing follicular dendritic cells (red) and B cells (green). C, Abundant high endothelial venules (red) and T-cell infiltration (green). Cell nuclei stained by 4′-6-diamidino-2-phenylindole, dihydrochloride (blue). Journal of Allergy and Clinical Immunology 2017 139, 1371-1373.e6DOI: (10.1016/j.jaci.2016.08.052) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Cluster dendrogram for correlations of the expression of TLO-related genes. Each dotted-line represents a cluster of genes that has statistically significant Pearson correlation (P < .05). Journal of Allergy and Clinical Immunology 2017 139, 1371-1373.e6DOI: (10.1016/j.jaci.2016.08.052) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions