Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis F. Bellucci,

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Presentation transcript:

Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis F. Bellucci, S. Meini, P. Cucchi, C. Catalani, A. Nizzardo, A. Riva, G.M. Guidelli, P. Ferrata, A. Fioravanti, C.A. Maggi Osteoarthritis and Cartilage Volume 21, Issue 11, Pages 1774-1780 (November 2013) DOI: 10.1016/j.joca.2013.08.014 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Correlation of basal and generated BK levels in SF of OA patients. Samples (n = 28) were extracted as described in Methods and measured by ELISA. Spearman's rank correlation coefficient (r) and the resulting P value are inserted. Osteoarthritis and Cartilage 2013 21, 1774-1780DOI: (10.1016/j.joca.2013.08.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Correlation between the VAS pain score and the Lequesne's algofunctional index in OA patients (n = 30). Spearman's rank correlation coefficient (r) and the resulting P value are inserted. Osteoarthritis and Cartilage 2013 21, 1774-1780DOI: (10.1016/j.joca.2013.08.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Correlation of basal and generated BK levels with GAGs (A-B, n = 20) and IL-6 (C-D, n = 28) in OA knee SF. Spearman's rank correlation coefficient (r) and the resulting P value are inserted. Osteoarthritis and Cartilage 2013 21, 1774-1780DOI: (10.1016/j.joca.2013.08.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Correlation of COMP, detected in OA SF, with the pain score (VAS) (A) and with the functional index score (Lequesne's index) (B) (n = 30). Spearman's rank correlation coefficient (r) and the resulting P value are inserted. Osteoarthritis and Cartilage 2013 21, 1774-1780DOI: (10.1016/j.joca.2013.08.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions