Abnormal embryonic development diagnosed embryoscopically in early intrauterine deaths after in vitro fertilization: A preliminary report of 23 cases  Tom Philipp, M.D., Wilfried Feichtinger, M.D., Margot I. Van Allen, M.D., Evica Separovic, M.D., Angelika Reiner, M.D., Dagmar K. Kalousek, M.D.  Fertility and Sterility  Volume 82, Issue 5, Pages 1337-1342 (November 2004) DOI: 10.1016/j.fertnstert.2004.04.057 Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 1 Case 20. Close up of a trisomy 3 (47,XY,+3) IVF embryo. The GD2 embryo, 3 mm in length, showed no recognizable external structures after the amnion had been opened. Fertility and Sterility 2004 82, 1337-1342DOI: (10.1016/j.fertnstert.2004.04.057) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 2 Case 13. Intact amniotic sac (A) containing a growth-disorganized IVF embryo 8 mm in length. The GD2 embryo is directly attached to the amnion. An apparently normal karyotype was diagnosed cytogenetically (46,XX). Fertility and Sterility 2004 82, 1337-1342DOI: (10.1016/j.fertnstert.2004.04.057) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 3 Case 16. Close-up lateral (a) and anterolateral (b) view of a macerated trisomy 13 (47,XY,+13) embryo after the amniotic membrane (A) had been opened. External developmental defects of the 15-mm-long embryo resulting from IVF are severe microcephaly, fusion of the face to the chest, and retarded limb development. The dark brown areas in the thoracic region are due to maceration; umbilical cord (U). Fertility and Sterility 2004 82, 1337-1342DOI: (10.1016/j.fertnstert.2004.04.057) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions

FIGURE 4 Case 6. Lateral view of a macerated, microcephalic trisomy 14 (47,XX,+14) embryo. Upper (UL) and lower (LL) limbs of the 18-mm-long embryo resulting from IVF show hand and foot plate development. Digital rays are beginning to be apparent on the hands but are not notched, indicating retarded development for an embryo of this size. M marks the microforceps. Fertility and Sterility 2004 82, 1337-1342DOI: (10.1016/j.fertnstert.2004.04.057) Copyright © 2004 American Society for Reproductive Medicine Terms and Conditions