Virus shedding after human rhinovirus infection in children, adults and patients with hypogammaglobulinaemia V. Peltola, M. Waris, L. Kainulainen, J.

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Virus shedding after human rhinovirus infection in children, adults and patients with hypogammaglobulinaemia V. Peltola, M. Waris, L. Kainulainen, J. Kero, O. Ruuskanen Clinical Microbiology and Infection Volume 19, Issue 7, Pages E322-E327 (July 2013) DOI: 10.1111/1469-0691.12193 Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Proportion of subjects positive for human rhinovirus (HRV) by RT-PCR in relation to days from onset of symptoms. The duration of HRV shedding was longer in patients with hypogammaglobulinaemia than in children or adults without hypogammaglobulinaemia (p <0.001, Log-rank test). Data are from 20 children and 21 adults (one infection episode per subject), and from 21 infection episodes in 13 subjects with hypogammaglobulinaemia. Clinical Microbiology and Infection 2013 19, E322-E327DOI: (10.1111/1469-0691.12193) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Representative human rhinovirus (HRV) shedding patterns and virus copy numbers during acute respiratory tract infections in an otherwise healthy child, an adult, and a patient with hypogammaglobulinaemia. HRV types were differentiated from each other by high-resolution melt analysis (Tm, mean ± SD °C). Dashed line shows the limit of detection. (a) An 8-year-old girl with three sequential HRV infections caused by different virus types. She had respiratory symptoms during the whole follow-up period. (b) A healthy adult with two sequential, symptomatic HRV infections caused by different virus types. (c) An adult with hypogammaglobulinaemia and chronic productive cough was positive for HRV in most samples for a long period. Some samples were negative for HRV, but high-resolution melt analysis confirmed a long-term infection by a single HRV type. Clinical Microbiology and Infection 2013 19, E322-E327DOI: (10.1111/1469-0691.12193) Copyright © 2013 European Society of Clinical Infectious Diseases Terms and Conditions