Resident Macrophages: Near and Dear to Your Heart

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Resident Macrophages: Near and Dear to Your Heart Nikhil V. Munshi Cell Volume 169, Issue 3, Pages 376-377 (April 2017) DOI: 10.1016/j.cell.2017.04.002 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Macrophage Functions in the Heart (A) The canonical function of macrophages in the heart includes innate immune surveillance. Resident macrophages (magenta) function to clear infectious agents (e.g. viruses and bacteria) in addition to necrotic cellular debris (not shown). (B) Non-canonical functions for macrophages in the heart. Macrophages (purple) are shown to electrically couple with surrounding cardiomyocytes in the atrioventricular node (AVN) via connexin 43 gap junctions (shown in yellow) to mediate cardiac conduction. Resident macrophages (purple) have also been found to secrete interleukin-1β. Cell 2017 169, 376-377DOI: (10.1016/j.cell.2017.04.002) Copyright © 2017 Elsevier Inc. Terms and Conditions