Monocyte recruitment in venous thrombus resolution

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Presentation transcript:

Monocyte recruitment in venous thrombus resolution Tahir Ali, MRCS, Julia Humphries, PhD, Kevin Burnand, Barbara Sawyer, Christina Bursill, PhD, Keith Channon, David Greaves, PhD, Barrett Rollins, MD, Israel F. Charo, MD, PhD, Alberto Smith, PhD Journal of Vascular Surgery Volume 43, Issue 3, Pages 601-608 (March 2006) DOI: 10.1016/j.jvs.2005.10.073 Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 1 A, Fluorescence activated cell sorting analysis of peritoneal lavage cells demonstrates the CD4+/CD3− macrophage population in the upper left-hand quadrant. B, Peritoneal lavage fluid cytospin shows an abundance of mononuclear cells (arrows) stained by the rat macrophage marker, ED1 (brown stain, ×100 original magnification). Journal of Vascular Surgery 2006 43, 601-608DOI: (10.1016/j.jvs.2005.10.073) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 2 125I-monocyte chemotactic protein 1 distribution in rat tissues for up to 7 days after direct injection into thrombus. IVC, Inferior vena cava. Journal of Vascular Surgery 2006 43, 601-608DOI: (10.1016/j.jvs.2005.10.073) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 3 Dose effect of monocyte chemotactic protein 1 (MCP1) (ng) on (A) recanalization and (B) thrombus size 7-days after thrombus induction. Values are ± SEM. Journal of Vascular Surgery 2006 43, 601-608DOI: (10.1016/j.jvs.2005.10.073) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 4 A, Longitudinal study of thrombus resolution in MCP−/− mice (grey circles) and wild-type controls (black circles) and in (B) CCR2−/− mice (grey circles) and wild-type controls (black circles). *Denotes intergroup significance (P < .05). Values are ± SEM. ANOVA, Analysis of variance. Journal of Vascular Surgery 2006 43, 601-608DOI: (10.1016/j.jvs.2005.10.073) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 5 A, Section of liver from ad.EGFP-treated mouse showing successful gene adenoviral transfection and EGFP expression (green fluorescence arrows, ×100 original magnification). B, Western blot of from five ad.35K transfected mice. The 35K protein and plasma from ad.EGFP treated animal were used as positive and negative controls respectively. Journal of Vascular Surgery 2006 43, 601-608DOI: (10.1016/j.jvs.2005.10.073) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 6 The effect of vaccinia virus-derived 35Kd protein blockade of C-C chemokines on (A) thrombus size and (B) thrombus recanalization harvested 14 days after tail vein gene transfer. Journal of Vascular Surgery 2006 43, 601-608DOI: (10.1016/j.jvs.2005.10.073) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions