Volume 14, Issue 3, Pages 253-262 (March 2015) Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross- sectional analysis  Jonathan D Rohrer, PhD, Jennifer M Nicholas, PhD, David M Cash, PhD, Prof John van Swieten, MD, Elise Dopper, MD, Lize Jiskoot, MSc, Rick van Minkelen, PhD, Prof Serge A Rombouts, PhD, M Jorge Cardoso, PhD, Shona Clegg, BSc, Miklos Espak, PhD, Simon Mead, PhD, David L Thomas, PhD, Enrico De Vita, PhD, Mario Masellis, MD, Prof Sandra E Black, MD, Prof Morris Freedman, MD, Ron Keren, MD, Bradley J MacIntosh, PhD, Ekaterina Rogaeva, PhD, David Tang-Wai, MD, Maria Carmela Tartaglia, MD, Robert Laforce, MD, Fabrizio Tagliavini, MD, Pietro Tiraboschi, MD, Veronica Redaelli, MD, Sara Prioni, MSc, Marina Grisoli, MD, Barbara Borroni, MD, Prof Alessandro Padovani, MD, Daniela Galimberti, PhD, Elio Scarpini, MD, Andrea Arighi, MD, Giorgio Fumagalli, MD, James B Rowe, PhD, Ian Coyle-Gilchrist, MB, Prof Caroline Graff, MD, Marie Fallström, MSc, Vesna Jelic, MD, Anne Kinhult Ståhlbom, PhD, Christin Andersson, PhD, Håkan Thonberg, PhD, Lena Lilius, BSc, Prof Giovanni B Frisoni, MD, Giuliano Binetti, Michela Pievani, PhD, Martina Bocchetta, MSc, Luisa Benussi, PhD, Roberta Ghidoni, PhD, Elizabeth Finger, MD, Prof Sandro Sorbi, MD, Benedetta Nacmias, PhD, Gemma Lombardi, MD, Cristina Polito, PhD, Prof Jason D Warren, PhD, Prof Sebastien Ourselin, PhD, Prof Nick C Fox, MD, Prof Martin N Rossor, MD  The Lancet Neurology  Volume 14, Issue 3, Pages 253-262 (March 2015) DOI: 10.1016/S1474-4422(14)70324-2 Copyright © 2015 Rohrer et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure Standardised difference between all mutation carriers and non-carriers in cortical grey matter volumetric imaging measures versus estimated years from expected symptoms onset Individual datapoints not plotted to prevent disclosure of genetic status. The time at which the upper 95% CI for each curve crosses zero on the y-axis (ie, the point at which a significant difference exists between mutation carriers and non-carriers) is shown on the x-axis. Individual curves with 95% CIs are shown in the appendix. Subcortical and cerebellar volumes are also shown in the appendix. The Lancet Neurology 2015 14, 253-262DOI: (10.1016/S1474-4422(14)70324-2) Copyright © 2015 Rohrer et al. Open Access article distributed under the terms of CC BY Terms and Conditions