Bioresorbable Vascular Scaffolds in Cardiac Allograft Vasculopathy: A New Therapeutic Option Flavio Ribichini, MD, Michele Pighi, MD, Giuseppe Faggian,

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Bioresorbable Vascular Scaffolds in Cardiac Allograft Vasculopathy: A New Therapeutic Option Flavio Ribichini, MD, Michele Pighi, MD, Giuseppe Faggian, MD, Corrado Vassanelli, MD The American Journal of Medicine Volume 126, Issue 11, Pages e11-e14 (November 2013) DOI: 10.1016/j.amjmed.2013.05.025 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Right anterior oblique angiographic incidence of the left coronary artery showing a long and tight stenosis of the middle segment (arrow). (First lower panel) Gray-scale intravascular ultrasound (IVUS) images: (a) section of the proximal vessel showing mild neointima and preserved lumen area but clear calcifications of the medial arterial layer; (b) proximal edge of the plaque with an empty core; (c) large plaque burden with lipid core causing minimum lumen area; (d) distal edge of the plaque showing moderate soft plaque; (e) distal vessel with a good lumen area. (Second lower panel) Virtual histology (VH) intravascular ultrasound (IVUS) images: (a) VH confirmation of the fibrocalcific plaque composition of the proximal vessel wall; (b) fibroatheromatous aspect with lipid core and calcific spots; (c) thin-cap fibroatheroma at the site of minimum lumen area; (d) pathological intimal thickening; (e) fibrotic distal vessel. The American Journal of Medicine 2013 126, e11-e14DOI: (10.1016/j.amjmed.2013.05.025) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Left anterior oblique angiographic incidence of the right coronary artery showing a moderate stenosis of the proximal segment (arrow). Gray-scale intravascular ultrasound (IVUS) images and co-respective virtual histology: (a) section of the proximal vessel showing pathological intimal thickening; (b) fibrocalcific plaque; (c) thick-cap fibroatheroma with lipid core; (d) fibrocalcific distal edge of the plaque. The American Journal of Medicine 2013 126, e11-e14DOI: (10.1016/j.amjmed.2013.05.025) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 3 Right anterior oblique angiographic incidence of the left coronary artery after implantation of one ABSORB scaffold 3.0 × 28 mm in the middle segment (between arrows). (First lower panel) Gray-scale intravascular ultrasound (IVUS) images showing complete coverage of the lesion and good expansion of the scaffold to the vessel wall. (Second lower panel) Virtual histology IVUS images of the same segment. The American Journal of Medicine 2013 126, e11-e14DOI: (10.1016/j.amjmed.2013.05.025) Copyright © 2013 Elsevier Inc. Terms and Conditions