Synaptogenesis: A Balancing Act between Excitation and Inhibition Hollis Cline  Current Biology  Volume 15, Issue 6, Pages R203-R205 (March 2005) DOI: 10.1016/j.cub.2005.03.010 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 Neuroligin–β-neurexin signaling and synaptogenesis. This model incorporates data from several papers, but is not yet proven by any. Neuroligin isoforms NL-1, NL-3 or NL-4, in association with PSD95, are postulated to induce formation of excitatory synapses, while NL-2, possibly associated with an as yet unidentified PSD95-like partner, leads to inhibitory synapse formation. This model predicts that NL-2 in association with the unknown partner, will be concentrated at neuronal somata, which are rich in GABAergic synapses. Current Biology 2005 15, R203-R205DOI: (10.1016/j.cub.2005.03.010) Copyright © 2005 Elsevier Ltd Terms and Conditions