What's so Bor(a)ing about Aurora-A Activation?

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Presentation transcript:

What's so Bor(a)ing about Aurora-A Activation? Christiane Wiese, Lori L. O'Brien Developmental Cell Volume 11, Issue 2, Pages 133-134 (August 2006) DOI: 10.1016/j.devcel.2006.07.011 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 A Model for the Mechanism of Aurora-A Activation by Bora Bora resides in the nucleus until it is released in a Cdc2-dependent manner. Release of Bora into the cytoplasm (and/or some unknown modification) allows it to associate with Aurora-A. The Aurora-A/Bora complex now activates centrosome maturation and asymmetric cell division. Whether Bora also plays roles in spindle assembly, chromosome alignment, and/or mitotic exit remains to be examined. Developmental Cell 2006 11, 133-134DOI: (10.1016/j.devcel.2006.07.011) Copyright © 2006 Elsevier Inc. Terms and Conditions