The Cell Biology of the Unfolded Protein Response

Slides:

Advertisements

Similar presentations

Increased Levels of Arginase in Patients With Acute Hepatitis B Suppress Antiviral T Cells Elena Sandalova, Diletta Laccabue, Carolina Boni, Tsunamasa.

Advertisements

Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells Lin Wang, Xiangdong Wang, Lei.

American Gastroenterological Association Institute Technical Review on the Management of Acute Diverticulitis Lisa L. Strate, Anne F. Peery, Ignacio.

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

Pancreatic Fusion Abnormality Found During a Whipple Procedure

Reconstitution of Normal Hepcidin Expression in Hfe-Deficient Mice After Liver Transplantation: A New Role of HFE in Kupffer Cells? Ivana De Domenico,

Cellular and Molecular Mechanisms of Liver Injury

Yang Tai, Huan Tong, Chengwei Tang Gastroenterology

A Novel ER Stress-Independent Function of the UPR in Angiogenesis

An Unusual Cause of Lower Gastrointestinal Bleeding

Cellular and Molecular Mechanisms of Liver Injury

The Value of a 24/7 Online Nationwide Multidisciplinary Expert Panel for Acute Necrotizing Pancreatitis Janneke van Grinsven, Sandra van Brunschot Gastroenterology

c-Kit as a Novel Potential Therapeutic Target in Colorectal Cancer

Do Diabetes Drugs Modify the Risk of Pancreatic Cancer?

Covering the Cover Gastroenterology

Spontaneous Self-Expulsion of a Large Stone From the Abdomen

Lost in Inflammation: The Functional Conversion of Regulatory T Cells in Acute Hepatitis A Virus Infection Tobias Boettler, Robert Thimme Gastroenterology

Ira J. Fox, Stephen C. Strom Gastroenterology

A Novel ER Stress-Independent Function of the UPR in Angiogenesis

Gastroenterology 2011–2016: Looking Back and Forward

Electronic Clinical Challenges and Images in GI

Making Sense of HDAC2 Mutations in Colon Cancer

GLP-1–Based Therapies: The Dilemma of Uncertainty

Clinical Challenges and Images in GI

Unusual Case of an Upset Stomach

Volume 153, Issue 3, Pages e16-e17 (September 2017)

Volume 135, Issue 4, Pages (October 2008)

A Historical Perspective on Clinical Advances in Pancreatic Diseases

Volume 150, Issue 4, Pages (April 2016)

A Sweet Discovery Gastroenterology

Progressive Dysphagia in a Pregnant Woman

American Gastroenterological Association Institute Technical Review on the Management of Acute Diverticulitis Lisa L. Strate, Anne F. Peery, Ignacio.

A Rare Cause of Postprandial Abdominal Pain and Nausea

Volume 145, Issue 1, Pages (July 2013)

Volume 137, Issue 1, Pages (July 2009)

Singling Out Intestinal Epithelial Stem Cells

An Unusual Case Presented With Multiple Liver Cystic Lesions

Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel Disease Arthur Kaser, Richard S. Blumberg

Laura Rotundo, Sushil Ahlawat Gastroenterology

HCV, Iron, and Oxidative Stress: The New Choreography of Hepcidin

Acute Respiratory Failure During Systemic Chemotherapy

Volume 139, Issue 2, Pages e3 (August 2010)

Ashwin N. Ananthakrishnan, David Lieberman Gastroenterology

Volume 148, Issue 3, Pages (March 2015)

A Challenging Case of Splenomegaly and Refractory Thrombocytopenia

Yoshitaka Nishikawa, Takaki Sakurai, Shin’ichi Miyamoto

Gastric Rupture Gastroenterology

Volume 150, Issue 7, Pages (June 2016)

Electronic Clinical Challenges and Images in GI

Esophageal Cytology: A Tale of Shish Kebab and Roman Legionaries

The Dawning of a New Editorial Board for Gastroenterology

Siddharth Singh, Matthew T. Howard, Konstantinos A. Papadakis

Changing of the Guards: 2011–2016 Gastroenterology Team

Electronic Clinical Challenges and Images in GI

A “Crescent-in-doughnut” Lesion at Right Lower Quadrant Abdomen

A Surprising Case of Acute Diarrhea in the South of France

Electronic Clinical Challenges and Images in GI

Volume 155, Issue 6, Pages (December 2018)

Volume 139, Issue 6, Pages e1 (December 2010)

Capecitabine-Induced Enteritis Leading to Small Bowel Obstruction

Reinvesting in US Biomedical Research—The Time is Now

A Necrotic Liver Mass Gastroenterology

Electronic Clinical Challenges and Images in GI

Controversies in Liver Transplantation for Hepatitis C

Tawfik Khoury, Eran Israeli, Shaul Yaari Gastroenterology

Reconstitution of Normal Hepcidin Expression in Hfe-Deficient Mice After Liver Transplantation: A New Role of HFE in Kupffer Cells? Ivana De Domenico,

Unrelenting Abdominal Pain after Recent Initiation of a Direct Oral Anticoagulant: A Cause for Concern Nicholas R. Crews, Nabil Fayad Gastroenterology

Volume 146, Issue 4, Pages (April 2014)

Abnormal Gastrointestinal Imaging in a Patient With Dyspepsia

A Rare Tumor of the Liver With a Sudden Presentation

Presentation transcript:

The Cell Biology of the Unfolded Protein Response J. Alan Diehl, Serge Y. Fuchs, Costantinos Koumenis Gastroenterology Volume 141, Issue 1, Pages 38-41.e2 (July 2011) DOI: 10.1053/j.gastro.2011.05.018 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 UPR signal transduction. ER stress signals induce UPR via promoting the activation of homologous transmembrane protein kinases, Ire1a/b, and PERK and a transmembrane transcription factor, ATF6. These regulators collectively transduce signals resulting in the up-regulation of ER chaperones and CHOP while simultaneously down-regulating cellular protein synthesis and including that of the growth promoter cyclin D1, thereby inducing growth arrest. Gastroenterology 2011 141, 38-41.e2DOI: (10.1053/j.gastro.2011.05.018) Copyright © 2011 AGA Institute Terms and Conditions