Redefining advanced maternal age as an indication for preimplantation genetic screening Miguel Milán, Ana Cristina Cobo, Lorena Rodrigo, Emilia Mateu,

Slides:

Advertisements

Similar presentations

Impact of positive hepatitis B surface antigen on the outcome of IVF treatment Vivian Chi Yan Lee, Ernest Hung Yu Ng, William Shu Biu Yeung, Pak Chung.

Advertisements

Mostafa Metwally, Cynthia M. Farquhar, Tin Chiu Li

Effect of androgen supplementation or modulation on ovarian stimulation outcome in poor responders: a meta-analysis Sesh Kamal Sunkara, Jyotsna Pundir,

Programmes and prospects for ovotechnology

Meiosis errors in over 20,000 oocytes studied in the practice of preimplantation aneuploidy testing Anver Kuliev, Zev Zlatopolsky, Irina Kirillova, Julia.

Kay Neumann, Georg Griesinger Reproductive BioMedicine Online

Nina Desai, Faten AbdelHafez, Mohamed A

Low-dosage clomiphene reduces premature ovulation rates and increases transfer rates in natural-cycle IVF M von Wolff, M Nitzschke, P Stute, N Bitterlich,

Bruce S. Shapiro, Said T. Daneshmand, Humberto Restrepo, Forest C

Group culture of human zygotes is superior to individual culture in terms of blastulation, implantation and life birth T. Ebner, O. Shebl, M. Moser,

MiR-483–5p and miR-486–5p are down-regulated in cumulus cells of metaphase II oocytes from women with polycystic ovary syndrome Lin Shi, Shan Liu, Wanqiu.

No association between endogenous LH and pregnancy in a GnRH antagonist protocol: part II, recombinant FSH George Griesinger, Daniel B. Shapiro, Efstratios.

In vitro maturation improves oocyte or embryo cryopreservation outcome in breast cancer patients undergoing ovarian stimulation for fertility preservation

L. L. van Loendersloot, M. van Wely, S. Repping, F. van der Veen, P. M

External quality control for embryology laboratories

Follicular-fluid anti-Mullerian hormone concentrations are predictive of assisted reproduction outcome in PCOS patients Recai Pabuccu, Cemil Kaya, Gamze.

Fresh transfer outcome predicts the success of a subsequent frozen transfer utilizing blastocysts of the same cohort L.F. Doherty, J.R. Martin, U. Kayisli,

A. Cobo, Nicolás Garrido, Juana Crespo, Remohí José, Antonio Pellicer

Asymptomatic adenomyosis and embryo implantation in IVF cycles

Anti-Müllerian hormone as a predictor of pregnancy following IVF

Semra Kahraman, Zafer Nihat Candan Reproductive BioMedicine Online

Cytoplasm replacement following germinal vesicle transfer restores meiotic maturation and spindle assembly in meiotically arrested oocytes John Zhang,

Inositol supplementation in women with polycystic ovary syndrome undergoing intracytoplasmic sperm injection: a systematic review and meta-analysis of.

Why are reproductive cancers more common in nulliparous women?

Clinical experience and perinatal outcome of blastocyst transfer after coculture of human embryos with human endometrial epithelial cells: a 5-year follow-up.

Hillary B. Alberta, Roberta M. Berry, Aaron D. Levine

S Munné, E Fragouli, P Colls, MG Katz-Jaffe, WB Schoolcraft, D Wells

Working to eliminate multiple pregnancies: a success story in Québec

Improvements achieved in an oocyte donation program over a 10-year period: sequential increase in implantation and pregnancy rates and decrease in high-order.

Effect of N-acetyl-cysteine after ovarian drilling in clomiphene citrate-resistant PCOS women: a pilot study A. Nasr Reproductive BioMedicine Online

Does early morphology provide additional selection power to blastocyst selection for transfer? F. Guerif, M. Lemseffer, J. Leger, R. Bidault, V. Cadoret,

Cumulative live-birth delivery after IVF/ICSI since the progressive introduction of single- embryo transfer D. De Neubourg, C. Daels, M. Elseviers, K.

Individual demands of human embryos on IVF culture medium: influence on blastocyst development and pregnancy outcome B. Wirleitner, P. Vanderzwalmen,

Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis Neelam Potdar, Tarek Gelbaya, Luciano G.

Effect of energy expenditure and physical activity on the outcomes of assisted reproduction treatment Mert Kucuk, Fadime Doymaz, Bulent Urman Reproductive.

Corifollitropin alfa versus recombinant follicle-stimulating hormone: an individual patient data meta-analysis Georg Griesinger, Robert Boostanfar, Keith.

Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis Chun Yang, Yuhong Geng, Yanhui Li, Chunyan Chen,

Oocyte vitrification in the 21st century and post-warming fertility outcomes: a systematic review and meta-analysis Neelam Potdar, Tarek A Gelbaya, Luciano.

Morphological systems of human embryo assessment and clinical evidence

Influence of paternal age on ongoing pregnancy rate at eight weeks' gestation in assisted reproduction Aukje Marieke Meijerink, Liliana Ramos, Kathrin.

Jyotsna Pundir, Sesh Kamal Sunkara, Tarek El-Toukhy, Yacoub Khalaf

Mostafa Metwally, Cynthia M. Farquhar, Tin Chiu Li

Ronit Machtinger, Raoul Orvieto Reproductive BioMedicine Online

Impact of positive hepatitis B surface antigen on the outcome of IVF treatment Vivian Chi Yan Lee, Ernest Hung Yu Ng, William Shu Biu Yeung, Pak Chung.

Aggregated chromosomes transfer in human oocytes

Cumulative live-birth rates per total number of embryos needed to reach newborn in consecutive in vitro fertilization (IVF) cycles: a new approach to.

The relationship between sperm head retardance using polarized light microscopy and clinical outcomes Belinda G. Vermey, Michael G. Chapman, Simon Cooke,

Mid-luteal serum progesterone concentrations govern implantation rates for cryopreserved embryo transfers conducted under hormone replacement John L.

Donor information considered important to donors, recipients and offspring: an Australian perspective I.S. Rodino, P.J. Burton, K.A. Sanders Reproductive.

Impact of vitamin D levels on ovarian reserve and ovarian response to ovarian stimulation in oocyte donors Alberta Maria Fabris, Maria Cruz, Carlos Iglesias,

Alexis Adler, Hsaio-Ling Lee, David H

S. Seshadri, S.K. Sunkara, Y. Khalaf, T. El-Toukhy, H. Hamoda

Follicle recruitment determines IVF productivity rate via the number of embryos frozen and subsequent transfers James D. Stanger, John L. Yovich Reproductive.

Should we be promoting embryo transfer at blastocyst stage?

Clinical significance of first-trimester intrauterine haematomas detected in pregnancies achieved by IVF-embryo transfer Lan Xiang, Zhaolian Wei, Juan.

Pietro Gambadauro, Ramesan Navaratnarajah

Selection of embryos for transfer in IVF: ranking embryos based on their implantation potential using morphological scoring Laura van Loendersloot, Madelon.

Jeff G. Wang, Nataki C. Douglas, Gary S. Nakhuda, Janet M

Testosterone concentrations in early pregnancy: relation to method of conception in an infertile population Ruth B. Lathi, Sharon E. Moayeri, Charitha.

Nigel Pereira, Anna Voskuilen-Gonzalez, Kolbe Hancock, Jovana P

Ovarian reserve screening before contraception?

Mariana M. Piccolomini, Mariana Nicolielo, Tatiana C. S

Live birth following early follicular phase oocyte collection and vitrified-warmed embryo transfer 8 days later Safak Hatırnaz, Ebru Hatırnaz, Baris.

Implantation of fresh and thawed–warmed embryos in single embryo transfer cycles: interpreting the initial beta-HCG Cynthia K. Sites, Peter St Marie,

Programmes and prospects for ovotechnology

John Yovich, James Stanger, Peter Hinchliffe

Impact of different patterns of sperm chromosomal abnormalities on the chromosomal constitution of preimplantation embryos Lorena Rodrigo, B.Sc., Vanessa.

A. Finn, L. Scott, Thomas O’Leary, D. Davies, J. Hill

In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study Carmen Rubio,

High oestradiol concentration after ovarian stimulation is associated with lower maternal serum beta-HCG concentration and neonatal birth weight Suying.

Presentation transcript:

Redefining advanced maternal age as an indication for preimplantation genetic screening Miguel Milán, Ana Cristina Cobo, Lorena Rodrigo, Emilia Mateu, Amparo Mercader, Pilar Buendía, Vanessa Peinado, Arantzazu Delgado, Pere Mir, Carlos Simón, José Remohí, Antonio Pellicer, Carmen Rubio Reproductive BioMedicine Online Volume 21, Issue 5, Pages 649-657 (November 2010) DOI: 10.1016/j.rbmo.2010.06.020 Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Chromosomal abnormalities found in embryos from advanced maternal age patients. (A) The percentage of abnormal embryos increased progressively with maternal age. (B) The percentage remained constant irrespective of the number of metaphase II (MII) oocytes retrieved after ovarian stimulation. Reproductive BioMedicine Online 2010 21, 649-657DOI: (10.1016/j.rbmo.2010.06.020) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Clinical outcome according to maternal age. (A) The number of embryo transfers was significantly higher in patients 38 and 39years old in the non-PGS group when compared with the PGS group (P<0.05), but was comparable in patients ⩾40years old. (B) Improved ongoing implantation rates (IR) were observed in the PGS group, with higher differences in patients ⩾41years of age. (C) A trend towards higher ongoing pregnancy rate per oocyte retrieval (PR/OR) was observed for non-PGS groups in patients 38 and 39years of age, whereas a change of trend was observed from 40years onwards, with an improvement of ongoing pregnancy rate per oocyte retrieval with PGS. ∗P<0.0001, #P<0.05, †P<0.01. Reproductive BioMedicine Online 2010 21, 649-657DOI: (10.1016/j.rbmo.2010.06.020) Copyright © 2010 Reproductive Healthcare Ltd. Terms and Conditions