Challenges of Recruitment in Haematology Trials Lorraine Jacques, R&D Project Manager © The Royal Wolverhampton Hospitals NHS Trust

Challenges of Recruitment in Haematology Trials Recruitment Issues Attraction of Sponsors to site Study portfolio for RWHT Patient Recruitment for RWHT © The Royal Wolverhampton Hospitals NHS Trust

Patient Recruitment Issues General Trial reasons: “I don’t want to be treated as a guinea pig” “I know someone who was on a trial who died” But more often than not in Haematology studies: Smaller patient population Frequency of visits can be very intense and complex Staff time © The Royal Wolverhampton Hospitals NHS Trust

Attraction of Sponsors to Site R&D Infrastructure: Approval times e.g. 30 day approval Integration of research culture e.g. Department Managers engaged Staffing levels increased Delivery of patient recruitment targets © The Royal Wolverhampton Hospitals NHS Trust

Attraction of Sponsors to Site Feasibility completion Diverse Haematology portfolio Sub-specialties Types of studies International Phase III/ Non-interventional NIHR adopted Collaboration with Universities Own Account with external companies © The Royal Wolverhampton Hospitals NHS Trust

RWHT Research Portfolio Print Master Studies: (New opened by year) © The Royal Wolverhampton Hospitals NHS Trust

RWHT Research Portfolio Print Master Studies: (Currently Active 11/12) 35 Active – 10 in Follow-up © The Royal Wolverhampton Hospitals NHS Trust

RWHT Research Portfolio Print Master Recruitment: 702 © The Royal Wolverhampton Hospitals NHS Trust

RWHT Research Portfolio Recruitment into RCTs: 73 patients recruited into RCTs in last 3 years © The Royal Wolverhampton Hospitals NHS Trust

The Future…… RWHT Attract diverse range of Sponsors: National/ international Commercial/ portfolio/ Non-commercial