The role of basophil activation test in allergic bronchopulmonary aspergillosis and Aspergillus fumigatus sensitization in cystic fibrosis patients Anna.

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Presentation transcript:

The role of basophil activation test in allergic bronchopulmonary aspergillosis and Aspergillus fumigatus sensitization in cystic fibrosis patients Anna Katelari, Marianna Tzanoudaki, Maria Noni, Maria Kanariou, Maria Theodoridou, Emmanuel Kanavakis, Stavros-Eleftherios Doudounakis, Christina Kanaka-Gantenbein Journal of Cystic Fibrosis Volume 15, Issue 5, Pages 587-596 (September 2016) DOI: 10.1016/j.jcf.2016.02.004 Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Basic gating strategy for the study of CD63 (A1–A4 and B1–B3) and CD203c (C1–C4) on basophils. For CD63 testing, basophils were defined as CD123+HLADRlowSSlow events (A1,A2), or as IgE+SSlow events (B1), whereas for CD203c testing, basophils were defined as CD3−CRTH2+SSlow events (C1,C2). Gating of A. fumigatus-activated basophil population (A4, B3 and C4) was based on the respective unstimulated control scatter plot (A3, B2 and C3). Journal of Cystic Fibrosis 2016 15, 587-596DOI: (10.1016/j.jcf.2016.02.004) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 CD63 and CD203c discriminatory power, according to the receiver operating characteristic (ROC) curve. Journal of Cystic Fibrosis 2016 15, 587-596DOI: (10.1016/j.jcf.2016.02.004) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 . Survival curves of patients based on CD203c and CD63 best cutoff values. Journal of Cystic Fibrosis 2016 15, 587-596DOI: (10.1016/j.jcf.2016.02.004) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions