B. Bittersohl, F. R. Miese, H. S. Hosalkar, M. Herten, G. Antoch, R

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T2∗ mapping of hip joint cartilage in various histological grades of degeneration B. Bittersohl, F.R. Miese, H.S. Hosalkar, M. Herten, G. Antoch, R. Krauspe, C. Zilkens Osteoarthritis and Cartilage Volume 20, Issue 7, Pages 653-660 (July 2012) DOI: 10.1016/j.joca.2012.03.011 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Upper left corner: cartilage-bone block including the ROI and histological cutting orientation (blue lines), which could be reproduced based on anatomical landmarks and appearance of the Ethipins®. By means of MPR software, DESS (upper right corner) and T2∗ reformats (lower right corner) were created that correlated with histological sections (lower left corner). Within each section (histological, DESS and T2∗ section) three regions (A, B, C) were identified for subsequent comparison (full-thickness ROI analyses). Some drill holes (left upper corner) depict areas where cartilage samples were harvested for quantitative analyses (data not shown). Osteoarthritis and Cartilage 2012 20, 653-660DOI: (10.1016/j.joca.2012.03.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 ROI analysis in corresponding DESS MRI (A), histological cut (B) and T2∗ map (C) at two regions. One region (white arrow) could not be mapped due to severe cartilage loss. This region and similar regions with full-thickness loss were excluded from further analyses. Osteoarthritis and Cartilage 2012 20, 653-660DOI: (10.1016/j.joca.2012.03.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Total Mankin score distribution in this case series. Osteoarthritis and Cartilage 2012 20, 653-660DOI: (10.1016/j.joca.2012.03.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Corresponding histological (A), DESS MRI (B) and T2∗ evaluation (C) revealing normal cartilage. Osteoarthritis and Cartilage 2012 20, 653-660DOI: (10.1016/j.joca.2012.03.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Box plot diagram illustrating the significant drop of T2∗ relative to the grade of cartilage degeneration ranging from 36.3 ± 4.3 ms in grade 0 regions to 22.8 ± 4.3 ms in regions with grade III changes. Osteoarthritis and Cartilage 2012 20, 653-660DOI: (10.1016/j.joca.2012.03.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 6 Corresponding DESS MRI (A), histological cut (B), and T2∗ map (C). Note the cartilage irregularities (black brackets) that are clearly depicted at the T2∗ map whereas no changes are demonstrated on the DESS image. Osteoarthritis and Cartilage 2012 20, 653-660DOI: (10.1016/j.joca.2012.03.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions