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* Figure 2: * *

Prenatal RB1 mutation detection Negative 0 % risk Positive 100 % risk No Screening required Planned late preterm or early term delivery (36/37 weeks) Flow chart Clinical tumors at birth 20 % probability No clinical tumors at birth 80 % probability Manage per standard practice according to staging OCT-guided posterior pole screening No tumor detected Clinical tumors detected Invisible tumor detected Tight follow up Every 2weeks for 3 months Every 3 weeks for 3 months Every 4 weeks for 6 months OCT-guided localization and photocoagulation Invisible tumor detected