The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: A systematic review and meta-analysis of randomized controlled trials

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Presentation transcript:

The risk of asthma exacerbation after stopping low-dose inhaled corticosteroids: A systematic review and meta-analysis of randomized controlled trials Matthew A. Rank, MD, John B. Hagan, MD, Miguel A. Park, MD, Jenna C. Podjasek, MD, Shefali A. Samant, MD, Gerald W. Volcheck, MD, Patricia J. Erwin, MLS, Colin P. West, MD, PhD Journal of Allergy and Clinical Immunology Volume 131, Issue 3, Pages 724-729.e2 (March 2013) DOI: 10.1016/j.jaci.2012.11.038 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 PRISMA flow diagram describing the steps of study selection.4 Journal of Allergy and Clinical Immunology 2013 131, 724-729.e2DOI: (10.1016/j.jaci.2012.11.038) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Asthma outcomes in patients who stop or continue ICSs. A, RR ratio of asthma exacerbation in patients who stop or continue ICSs. B, Mean FEV1 difference in patients who stop or continue ICSs. C, Mean morning PEF difference in patients who stop or continue ICSs. D, Standardized mean difference in asthma symptoms in patients who stop or continue ICSs. Journal of Allergy and Clinical Immunology 2013 131, 724-729.e2DOI: (10.1016/j.jaci.2012.11.038) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions