DAT Imaging in a cohort of p.A53T SNCA PD patients versus typical PD

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Presentation transcript:

DAT Imaging in a cohort of p.A53T SNCA PD patients versus typical PD

RATIONALE-DESIGN Few systematic imaging studies performed in carriers of the p.A53T SNCA mutation Only one such study for DAT Scans (Bostantjopoulou et al., 2008) In our study, comparison of 11 PPMI-entered p.A53T PD to 33 PPMI-entered PD subjects Age-, sex-, and disease duration-matched Correlation of DAT with neuropsychological tests More comprehensive analysis of differences between A53T and typical PD in non-motor function in Koros et al., Neurology, 90(10):e864-e869

RESULTS

CONCLUSIONS Lower caudate binding ratios No difference in asymmetry DAT Scan in p.A53T PD vs typical PD Lower caudate binding ratios No difference in asymmetry No correlation of caudate binding ratios with neuropsychological testing Higher LEDD Results indicative of a different topographical pattern of nigrostriatal degeneration or more severe disease in p.A53T PD