Protein Synthesis Overview

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Presentation transcript:

Protein Synthesis Overview pp 310-313

Relating DNA & Protein Archibald Garrod - early 20th century Physician that noticed that alkaptonuria were found in numerous members in a family Alkaptonuria Metabolic disorder where tyrosine is not properly broken down Causes a person’s urine to turn black in the air What was the importance of this work?

1941 – Beadle & Tatum First hypothesized that genes and enzymes are somehow related

Beadle & Tatum Experiment N. crassa – bread mould (yeast) This organism could grow given only salts, sugar and vitamin B It can make its own amino acid nutrients Used UV and X-rays These mutants were:

Beadle & Tatum Experiment Were also able to use their mutants to discover the pathways of amino acid synthesis

Beadle & Tatum Experiment Conclusions Hypothesized: Original: One gene-one enzyme theory Now: One gene-one polypeptide theory Be sure you can explain both of these theories and how they differ.

Central Dogma DNA mRNA protein COMPONENTS LOCATION PROCESS nucleus transcription mRNA cytoplasm translation protein