Recurrent Fevers, Cough, and Pulmonary Opacities in a Middle-Aged Man

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Recurrent Fevers, Cough, and Pulmonary Opacities in a Middle-Aged Man Philippe R. Bauer, MD, PhD, FCCP, Clive S. Zent, MD, Marie-Christine Aubry, MD, FCCP, Jay H. Ryu, MD, FCCP  CHEST  Volume 137, Issue 6, Pages 1465-1469 (June 2010) DOI: 10.1378/chest.09-1271 Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 1 Chest CT scan during the first episode showing diffuse centrilobular nodules highly suggestive of subacute hypersensitivity pneumonitis. CHEST 2010 137, 1465-1469DOI: (10.1378/chest.09-1271) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 2 Transbronchial lung biopsy specimen during the first episode. Photomicrograph shows intraalveolar plugs of proliferating fibroblasts in a myxoid background (hematoxylin and eosin stain; original magnification × 200). CHEST 2010 137, 1465-1469DOI: (10.1378/chest.09-1271) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 3 Chest radiograph during the second episode. Ill-defined hazy increased density in both bases is more pronounced on the left side, causing partial obscuration of the left hemidiaphragm. CHEST 2010 137, 1465-1469DOI: (10.1378/chest.09-1271) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 4 Chest CT scan during the second episode. Predominant pattern of randomly distributed (both centrilobular and subpleural) poorly defined nodular opacities (white arrows), more extensive than seen on the initial chest CT scan, with a noticeably different morphology and without evidence of air-space consolidation or ground glass attenuation. CHEST 2010 137, 1465-1469DOI: (10.1378/chest.09-1271) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 5 Chest radiograph during the second episode with worsening symptoms, showing increase in the diffuse nodular opacities throughout both lungs. CHEST 2010 137, 1465-1469DOI: (10.1378/chest.09-1271) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 6 Chest CT scan during the second episode with worsening symptoms. Progression of radiologic abnormalities to include diffuse, randomly distributed lung nodules, curvilinear subpleural consolidation and/or atelectasis involving the left base, and evidence of subtle increased peripheral/subpleural reticular densities in the posterior right lung base, suggesting the development of mild fibrosis. CHEST 2010 137, 1465-1469DOI: (10.1378/chest.09-1271) Copyright © 2010 The American College of Chest Physicians Terms and Conditions

Figure 7 Transbronchial lung biopsy specimen during the second episode. Photomicrograph shows intraalveolar plugs of proliferating fibroblasts in a myxoid background, similar to the previous biopsy specimen (hematoxylin and eosin stain; original magnification × 200). CHEST 2010 137, 1465-1469DOI: (10.1378/chest.09-1271) Copyright © 2010 The American College of Chest Physicians Terms and Conditions