Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial Jill.

Slides:

Advertisements

Similar presentations

High Hemoglobin A1c Associated with Increased Adverse Limb Events in Peripheral Arterial Disease Patients Undergoing Revascularization Shipra Arya, Zachary.

Advertisements

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease Joseph P. Archie, PhD, MD Journal of Vascular.

Outcomes of cold-stored venous allograft for below-knee bypasses in patients with critical limb ischemia Vincent Ziza, MD, Ludovic Canaud, MD, PhD, Thomas.

Limb salvage and outcomes among patients with traumatic popliteal vascular injury: An analysis of the National Trauma Data Bank Philip S. Mullenix, MD,

Comparison of popliteal artery aneurysm therapies

Autologous bone marrow mononuclear cell implantation therapy is an effective limb salvage strategy for patients with severe peripheral arterial disease

Balloon angioplasty versus Viabahn stent graft for treatment of failing or thrombosed prosthetic hemodialysis grafts Thomas Vesely, MD, William DaVanzo,

The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation Jeroen Otte, MD, MSc, Jaap J. van Netten,

Open surgery for atherosclerotic chronic mesenteric ischemia

Mortality rates and mortality predictors in patients with symptomatic peripheral artery disease stratified according to age and diabetes Thomas Mueller,

Andrew H. Stewart, FRCS, Paul S. Eyers, FRCS, Jonothan J

Smoking cessation is associated with decreased mortality and improved amputation- free survival among patients with symptomatic peripheral artery disease

Vein harvesting technique for infrainguinal arterial bypass with great saphenous vein and its association with surgical site infection and graft patency

Frequency of cancer in patients operated on for acute peripheral arterial thrombosis and the impact on prognosis Chalotte Winther Nicolajsen, MD, Maja.

The Impact of Peripheral Vascular Disease on Long-Term Survival After Coronary Artery Bypass Graft Surgery Danny Chu, MD, Faisal G. Bakaeen, MD, Xing.

Jack R. W. Brownrigg, MBChB, Michelle Griffin, MBChB, Cian O

The association of chronic kidney disease and dialysis treatment with foot ulceration and major amputation Jeroen Otte, MD, MSc, Jaap J. van Netten,

Louis L. Nguyen, MD, MBA, MPH Journal of Vascular Surgery

Balloon angioplasty versus Viabahn stent graft for treatment of failing or thrombosed prosthetic hemodialysis grafts Thomas Vesely, MD, William DaVanzo,

Long-term safety of cilostazol in patients with peripheral artery disease: The CASTLE study (Cilostazol: A Study in Long-term Effects) William R. Hiatt,

The impact of gender on outcome after infrainguinal arterial reconstructions for peripheral occlusive disease Enzo Ballotta, MD, Mario Gruppo, MD, Renata.

LEA 25. Outcomes in Limb Preservation After Revascularization and Minor Amputations in 876 Patients With Peripheral Arterial Disease During a 9-Year Period

Contemporary outcomes after distal vertebral reconstruction

Long-term results of a multicenter randomized study on direct versus crossover bypass for unilateral iliac artery occlusive disease Jean-Baptiste Ricco,

The consequences of an outbreak of multidrug-resistant Pseudomonas aeruginosa among patients treated for critical leg ischemia Maria Söderström, MD,

Open versus endovascular treatment of subclavian artery atherosclerotic disease George C. Galyfos, MD, PhD, Ioannis Kakisis, MD, PhD, Chrisostomos Maltezos,

Katelynn M. Ferranti, MD, Turner M. Osler, MD, Reshma P

Cryopreserved saphenous vein graft in infrainguinal bypass

Reshma P. Duffy, MD, Julie E. Adams, MD, Peter W

Association of dual-antiplatelet therapy with reduced major adverse cardiovascular events in patients with symptomatic peripheral arterial disease Ehrin.

Combination therapy with warfarin plus clopidogrel improves outcomes in femoropopliteal bypass surgery patients Mario Monaco, MD, Luigi Di Tommaso, MD,

Vincent L. Rowe, MD, William Lee, MD, Fred A

Outcomes of infrainguinal bypass determined by age in the Vascular Study Group of New England Meghan Dermody, MD, MS, Christopher Homsy, MD, Yuanyuan.

Randomized comparison of ePTFE/nitinol self-expanding stent graft vs prosthetic femoral-popliteal bypass in the treatment of superficial femoral artery.

Results of PREVENT III: A multicenter, randomized trial of edifoligide for the prevention of vein graft failure in lower extremity bypass surgery Michael.

Current accepted hemodynamic criteria for critical limb ischemia do not accurately stratify patients at high risk for limb loss Raghuveer Vallabhaneni,

Perioperative outcomes and amputation-free survival after lower extremity bypass surgery in California hospitals, , with follow-up through 2004

Impact of statin therapy on patients with coronary heart disease and aortic aneurysm or dissection Junichi Tazaki, MD, Takeshi Morimoto, MD, PhD, Ryuzo.

Predictive factors for better bypass patency and limb salvage after prosthetic above- knee bypass reconstruction Eric Klingelhoefer, MD, Hendrik Bergert,

Thomas S. Huber, MD, PhD, Michael P. Brown, DO, James M. Seeger, MD, W

A comparison of tibial artery bypass performed with heparin-bonded expanded polytetrafluoroethylene and great saphenous vein to treat critical limb ischemia

Daniel J. Torrent, MD, MPH, Jill N. Zink, MD, William M. Bogey, MD, C

Benefits, morbidity, and mortality associated with long-term administration of oral anticoagulant therapy to patients with peripheral arterial bypass.

Lower extremity arterial reconstruction for critical limb ischemia in diabetes Enzo Ballotta, MD, Antonio Toniato, MD, Giacomo Piatto, MD, Franco Mazzalai,

Dual antiplatelet therapy (clopidogrel and aspirin) is associated with increased all-cause mortality after carotid revascularization for asymptomatic.

Comparison of open and endovascular treatment of patients with critical limb ischemia in the Vascular Quality Initiative Jeffrey J. Siracuse, MD, Matthew.

Jonathan Sobocinski, MD, PhD, Florent Briffa, MD, Peter J

Thomas E. Brothers, MD, Jacob G. Robison, MD, Bruce M. Elliott, MD

James T. McPhee, MD, Philip P

A personal experience with the influence of diabetes and other factors on the outcome of infrainguinal bypass grafts for occlusive disease Norman R.

Outcome of the FUSION vascular graft for above-knee femoropopliteal bypass Afshin Assadian, MD, Hans-Henning Eckstein, MD Afshin Assadian, MD, Felix Härtl,

Heparin-bonded Dacron or polytetrafluorethylene for femoropopliteal bypass: Five-year results of a prospective randomized multicenter clinical trial

Todd R. Vogel, MD, MPH, Robin L. Kruse, PhD

Comparative effectiveness of peripheral vascular intervention versus surgical bypass for critical limb ischemia in the Vascular Study Group of Greater.

Soma Brahmanandam, MD, MPH, Eric L. Ding, ScD, Michael S

Sequential compression biomechanical device in patients with critical limb ischemia and nonreconstructible peripheral vascular disease Sherif Sultan,

The consequences of an outbreak of multidrug-resistant Pseudomonas aeruginosa among patients treated for critical leg ischemia Maria Söderström, MD,

Composite sequential bypasses to the ankle and beyond for limb salvage

Glauco Milio, MD, Chiara Minà, MD, Valentina Cospite, MD, Piero L

Regarding “Vascular abnormalities in patients with neurofibromatosis syndrome type I: Clinical spectrum, management, and results” John B. Chang, MD,

Endovascular-first approach is not associated with worse amputation-free survival in appropriately selected patients with critical limb ischemia Karan.

Reply Journal of Vascular Surgery

Defining utility and predicting outcome of cadaveric lower extremity bypass grafts in patients with critical limb ischemia Catherine K. Chang, MD, Salvatore.

Differences in anatomy and outcomes in patients treated with open mesenteric revascularization before and after the endovascular era Evan J. Ryer, MD,

Midterm outcomes of the Zenith Renu AAA Ancillary Graft

Outcomes of cold-stored venous allograft for below-knee bypasses in patients with critical limb ischemia Vincent Ziza, MD, Ludovic Canaud, MD, PhD, Thomas.

A phase II dose-ranging study of the phosphodiesterase inhibitor K-134 in patients with peripheral artery disease and claudication Eric P. Brass, MD,

Francisco Alcocer, MD, Marjan Mujib, MD, Bruce Lowman, MD, Mark A

Axillary-to-carotid artery bypass grafting for symptomatic severe common carotid artery occlusive disease Joseph P. Archie, PhD, MD Journal of Vascular.

Results of a single center vascular screening and education program

Presentation transcript:

Results of the randomized, placebo-controlled clopidogrel and acetylsalicylic acid in bypass surgery for peripheral arterial disease (CASPAR) trial Jill J.F. Belch, MD, FRCP, John Dormandy, MD, FRCS Journal of Vascular Surgery Volume 52, Issue 4, Pages 825-833.e2 (October 2010) DOI: 10.1016/j.jvs.2010.04.027 Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 1 Clopidogrel and Acetylsalicylic acid in bypass Surgery for Peripheral Arterial disease (CASPAR) study design. R = randomization stratified by graft type (venous or prosthetic). ASA, Acetylsalicylic acid. Journal of Vascular Surgery 2010 52, 825-833.e2DOI: (10.1016/j.jvs.2010.04.027) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 2 Distribution of patients. ASA, Acetylsalicylic acid. Journal of Vascular Surgery 2010 52, 825-833.e2DOI: (10.1016/j.jvs.2010.04.027) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 3 Kaplan-Meier curves of time to primary outcome event (graft occlusion/revascularization/replacement, amputation above ankle, death) in the total population. CI, Confidence interval; NS, not significant. Journal of Vascular Surgery 2010 52, 825-833.e2DOI: (10.1016/j.jvs.2010.04.027) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 4 Kaplan-Meier curves of time to primary outcome event (graft occlusion/revascularization/replacement, amputation above ankle, death) by type of graft (intent-to-treat [ITT] population). CI, Confidence interval; NS, not significant. Journal of Vascular Surgery 2010 52, 825-833.e2DOI: (10.1016/j.jvs.2010.04.027) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

Fig 5 Kaplan-Meier curves of time to first amputation above the ankle of the affected limb: venous and prosthetic graft groups. CI, Confidence interval; NS, not significant. Journal of Vascular Surgery 2010 52, 825-833.e2DOI: (10.1016/j.jvs.2010.04.027) Copyright © 2010 Society for Vascular Surgery Terms and Conditions