Reproductive function in the sons of women who experienced stress due to bereavement before and during pregnancy: a nationwide population-based cohort.

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Reproductive function in the sons of women who experienced stress due to bereavement before and during pregnancy: a nationwide population-based cohort study Oleguer Plana-Ripoll, M.Sc., Jiong Li, M.D., Ph.D., Ulrik Schiøler Kesmodel, M.D., Ph.D., Erik Parner, Ph.D., Jørn Olsen, M.D., Ph.D., Olga Basso, Ph.D. Fertility and Sterility Volume 107, Issue 1, Pages 189-197.e8 (January 2017) DOI: 10.1016/j.fertnstert.2016.10.016 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Hazard ratios and 95% confidence intervals for [1] main composite outcome of infertility, congenital malformations of genital organs, and testicular cancer; [2] cryptorchidism (all cases); [3] cryptorchidism (surgically corrected); [4] hypospadias; [5] other malformations of genital organs; and [6] testicular cancer according to exposure to prenatal stress after maternal bereavement. Estimates in strata with fewer than five cases are not shown. Fertility and Sterility 2017 107, 189-197.e8DOI: (10.1016/j.fertnstert.2016.10.016) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Formation of the study population. Fertility and Sterility 2017 107, 189-197.e8DOI: (10.1016/j.fertnstert.2016.10.016) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Hazard ratios and 95% confidence intervals for [1] cryptorchidism (all cases); [2] cryptorchidism (surgically corrected); [3] hypospadias; and [4] other malformations of genital organs according to exposure to prenatal stress after maternal bereavement depending on the relationship between the mother and the deceased. Estimates in strata with fewer than five cases are not shown. Fertility and Sterility 2017 107, 189-197.e8DOI: (10.1016/j.fertnstert.2016.10.016) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Formation of the study population for the subanalysis considering infertility (excluding congenital malformations of genital organs and testicular cancer). Fertility and Sterility 2017 107, 189-197.e8DOI: (10.1016/j.fertnstert.2016.10.016) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions