Osteoarthritis and Cartilage

Slides:

Advertisements

Similar presentations

The progression of end-stage osteoarthritis: analysis of data from the Australian and Norwegian joint replacement registries using a multi-state model.

Advertisements

Micro-CT bone structure evaluation in the Pond-Nuki dog model

The epidemiology and impact of pain in osteoarthritis

Osteoarthritis and Cartilage

Osteoarthritis and Cartilage

K.S. Santangelo Osteoarthritis and Cartilage

S. Gavard Osteoarthritis and Cartilage

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T R. Colotti, P. Omoumi, R.B. van Heeswijk Osteoarthritis.

Changes in social isolation and loneliness following total hip and knee arthroplasty: longitudinal analysis of the English Longitudinal Study of Ageing.

Injectable hydrogels for cartilage repair

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Osteoarthritis year in review 2015: mechanics

Osteoarthritis and Cartilage

Role of endothelin-1 in endochondral ossification and osteoarthritis

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

Spatial variation of cartilage stiffness at micro and macro scale

Evaluation of TRB-n0224, a Chemically Modified Curcumin for the Treatment of Osteoarthritis R. Nixon, J. Coury, S.S. Shah, N. Chahine, T. Goldstein,

Preliminary study: non destructive evaluation of early cartilage morphological changes in a rabbit model by equilibrium partitioning of an ionic contrast.

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

Osteoarthritis and Cartilage

Time to be positive about negative data?

Defining the relationship between joint pathology and pain in osteoarthritis using genetically modified mice M.T. Jackson, S. Zaki, V. Ravi, B. Moradi,

Osteoarthritis and Cartilage

Investigating the role of bone microarchitecture in early osteoarthritis using new in vivo 3D high-resolution peripheral quantitative computed tomography

Volume 104, Issue 7, Pages (April 2013)

Legbrace limits maximum tibeofemoral force during gait

The influence of early osteoarthritic collagen network de-structuring in articular cartilage on the tissue stiffness and swelling properties M. Nickien,

Aggrecan fragments in the synovial fluid of osteoarthritis and juvenile idiopathic arthritis patients reveals differences in the specificity of aggrecanase.

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

The Differences of the Viscoelastic Behavior among Intra-articular Injections of Hyaluronan Formulation H. Hoshi, K. Miyamoto Osteoarthritis and Cartilage

N. Segal, E. Frick, M. Nevitt, J. Torner, D. Felson, A. Guermazi, D

Osteoarthritis and Cartilage

D.D. Anderson, A.M. Kern, T.J. Stockman, C.M. Findlay, N.A. Segal

Osteoarthritis and Cartilage

High-bandwidth atomic force microscopy (AFM) based rheology of murine cartilage reveals degeneration of collagen IX knock out mice cartilage compared.

A graphic user interface for the evaluation of knee osteoarthritis (GEKO): an open- source tool for histological grading H.E. Kloefkorn, B.Y. Jacobs,

Osteoarthritis and Cartilage

Who should have a joint replacement? A plea for more ‘phronesis’

A cartilage-targeted insulin-like growth factor-1 is retained in cartilage and promotes extracellular matrix maintenance in rat medial meniscus tear model

Structural Damage of the Thumb Base in Patients With Hand Osteoarthritis, Assessment by Magnetic Resonance Imaging Compared to Standard Radiography S.

Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI M.A. Bowes, B.T. Drew, A.C. Redmond, B.

Spontaneous home cage activity is sensitive to anti-NGF treatment or can be linked to joint stiffness in different models of surgery-induced osteoarthritis

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

N. Khalaj, N.A. Osman, W. Wan Abas, A. Mokhtar

Development of Asian hip stem 1 – Three dimensional morphology study

M. Baharuddin, S.-H. Salleh, M. Lee, A. Mohd Noor

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Osteoarthritis and Cartilage

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Osteoarthritis and Cartilage

A.B. Lovati, A. Pozzi, M. Bongio, C. Recordati, G. Berzero, M. Moretti

Morphological study of lateral meniscus using statistical shape modelling: a study using data from the osteoarthritis initiative K.Y. Zang, A.E. Kedgley,

P. Rahnamay Moshtagh, N. M. Korthagen, S. G. Plomp, B. Pouran, A

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

Fracture severity predicts OA risk following intra-articular fractures

Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure C.

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Nanoparticle targeting to cartilage: effects of surface charge on nanoparticle interactions with joint tissues S.B. Brown, B. Sharma Osteoarthritis.

Tibiofemoral joint loading during therapeutic exercises and activities of daily living: Implications for rehabilitation in osteoarthritis and cartilage.

Dancing transcription factors: What makes SOX9 move?

Comparative evaluations of matrix alterations in the ovine menisci following joint injury or reconstructive surgery K. Barton, M. Wiebe, Y. Achari, C.B.

The elastic modulus of articular cartilage at nano-scale and micro-scale measured using indentation type atomic force microscopy P. Rahnamay Moshtagh,

J.H. Ylärinne, C. Qu, M.J. Lammi Osteoarthritis and Cartilage

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Osteoarthritis and Cartilage

Does the meniscal symptom index include the symptoms most important for middle- aged patients with degenerative meniscal tears eligible for surgery? K.B.

Fully automated segmentation of cartilage from magnetic resonance images using improved 3D shape context and active shape model T. Ye, X. Cui, H. Kim

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Osteoarthritis and Cartilage Effect of aggrecanase and collagenase resistant knock-in, age and joint-overuse on murine cartilage M. Azadi, H.T. Nia, S.J. Gauci, F. Rogerson, C. Ortiz, A.J. Fosang, A.J. Grodzinsky Osteoarthritis and Cartilage Volume 23, (April 2015) DOI: 10.1016/j.joca.2015.02.822 Copyright © 2015 Terms and Conditions

Figure 1. (a) Representative histological image of aggrecanase resistant (Jaffa) joint morphology; (b) AFM micro-indentation measurement utilizing 2-3 μm approach-retract displacements (force-displacement tests) analyzed via the Hertz model; (c) AFM-based wide bandwidth nanodynamic assessment utilizing 2nm displacement amplitudes applied in the 1Hz to 10 kHz frequency range, to measure the equilibrium and high frequency stiffness, energy dissipation, and to compute hydraulic permeability. Osteoarthritis and Cartilage 2015 23, DOI: (10.1016/j.joca.2015.02.822) Copyright © 2015 Terms and Conditions

Figure 2. Data are mean ± SE n>3; indentation applied to >5 location on each joint surface. Osteoarthritis and Cartilage 2015 23, DOI: (10.1016/j.joca.2015.02.822) Copyright © 2015 Terms and Conditions