A. Williams, Y. Qian, C.R. Chu Osteoarthritis and Cartilage

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Presentation transcript:

UTE-T2∗ mapping of human articular cartilage in vivo: a repeatability assessment A. Williams, Y. Qian, C.R. Chu Osteoarthritis and Cartilage Volume 19, Issue 1, Pages 84-88 (January 2011) DOI: 10.1016/j.joca.2010.10.018 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative mono-exponential UTE-T2∗ curve fit at a single voxel. Black circles represent measured signal intensities in this voxel at each of the 11 ‘echo images.’ The black line represents the calculated mono-exponential UTE-T2∗ curve. The UTE-T2∗ value of this voxel is 21.8ms. TE images were acquired at 0.6, 1, 2, 3, 4, 5, 7, 10, 20, 30, 40ms. Osteoarthritis and Cartilage 2011 19, 84-88DOI: (10.1016/j.joca.2010.10.018) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Example in vivo UTE-T2∗ maps of a representative subject from the 3-day intersession repeatability analysis. Full-thickness, superficial and deep ROIs are outlined in the enlarged map below Day 2. Repeated measures of UTE-T2∗ values were stable within 8% RMSA-CV (1.2ms) for full-thickness ROIs like the central weight-bearing zone of the medial femoral condyle shown here. The cMFC UTE-T2∗ values for this subject were (Bulk, superficial, deep; mean±SD): Day 1 – 18±9, 27±3, 11±5; Day 2 – 22±10, 31±4, 14±6; Day 3 – 21±9, 29±5; 13±4. The cMTP UTE-T2∗ values for this subject were (Bulk, superficial, deep; mean±SD): Day 1 – 27±4, 27±2, 26±5; Day 2 – 25±4, 25±2, 25±5; Day 3 – 26±6, 31±4, 20±3. Osteoarthritis and Cartilage 2011 19, 84-88DOI: (10.1016/j.joca.2010.10.018) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 A representative UTE-T2∗ profile depicting the depthwise variation of UTE-T2∗ values across medial femoral condyle cartilage. UTE-T2∗ values are lowest in the deepest layer of cartilage, next to the subchondral bone, and increase toward the articular surface. Osteoarthritis and Cartilage 2011 19, 84-88DOI: (10.1016/j.joca.2010.10.018) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions